1. Ileal Pouch Anal Anastomosis for the Management of Ulcerative Colitis Is Associated With Significant Disability
- Author
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Jordan E. Axelrad, Ryan C. Ungaro, Maia Kayal, Keith Sultan, New York Crohn’s, Ellen Scherl, Marla Dubinsky, Adam S. Faye, Alexa Riggs, Kanika Kamal, Manasi Agrawal, Shirley Cohen-Mekelburg, Garrett Lawlor, Dana J. Lukin, and Jean-Frederic Colombel
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medicine.medical_specialty ,Colonic Pouches ,Inflammatory bowel disease ,Article ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Interquartile range ,Internal medicine ,medicine ,Humans ,Retrospective Studies ,Crohn's disease ,Hepatology ,Management of ulcerative colitis ,business.industry ,Proctocolectomy, Restorative ,Gastroenterology ,Odds ratio ,Colitis ,Inflammatory Bowel Diseases ,medicine.disease ,Ulcerative colitis ,Confidence interval ,Cross-Sectional Studies ,030220 oncology & carcinogenesis ,Colitis, Ulcerative ,Female ,030211 gastroenterology & hepatology ,Pouch ,business - Abstract
BACKGROUND: Disability in patients with medically refractory ulcerative colitis (UC) after total proctocolectomy (TPC) with ileal pouch anal anastomosis (IPAA) is not well understood. The aim of this study was to compare disability in patients with IPAA vs medically managed UC, and identify predictors of disability. METHODS: This was a multi-center cross-sectional study performed at five academic institutions in New York City. Patients with medically or surgically treated UC were recruited. Clinical and socioeconomic data were collected and the inflammatory bowel disease disability index (IBD-DI) was administered to eligible patients. Predictors of moderate-severe disability (IBD-DI≥35) were assessed in univariable and multivariable models. RESULTS: A total of 94 patients with IPAA and 128 patients with medically managed UC completed the IBD-DI. Among patients with IPAA and UC, 35 (37.2%) and 30 (23.4%) had moderate-severe disability, respectively. Patients with IPAA had significantly greater IBD-DI scores compared to patients with medically managed UC (29.8 vs 17.9, p
- Published
- 2022
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