1. Radiogenomic evaluation of lung cancer - Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations?
- Author
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Halpenny DF, Plodkowski A, Riely G, Zheng J, Litvak A, Moscowitz C, and Ginsberg MS
- Subjects
- Adenocarcinoma genetics, Adenocarcinoma pathology, Adult, Aged, Aged, 80 and over, Female, Humans, Lung Neoplasms genetics, Lung Neoplasms pathology, Male, Middle Aged, Tomography, X-Ray Computed, Adenocarcinoma diagnostic imaging, Lung Neoplasms diagnostic imaging, Mutation, Proto-Oncogene Proteins B-raf genetics
- Abstract
Introduction: We studied computed tomography (CT) features associated with BRAF mutated lung cancer., Materials and Methods: CT features of BRAF mutated lung cancers were compared to stage matched lesions without BRAF mutation., Results: 47 (25%) patients with BRAF mutation and 141 (75%) without BRAF mutation were included. BRAF lesions were most frequently solid 37 (84%), spiculated 22 (50%), and peripheral 37 (84%). No feature of the primary tumor was significantly different between BRAF and non-BRAF groups. BRAF patients were more likely than KRAS patients to have pleural metastases [5 (11%) vs 0 (0%), p=0.045]., Conclusion: No feature of the primary tumor differentiates BRAF lesions from non-BRAF lesions., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2017
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