1. Laboratory biomarkers associated with COVID-19 severity and management.
- Author
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Keddie, S., Ziff, O., Chou, M.K.L., Taylor, R.L., Heslegrave, A., Garr, E., Lakdawala, N., Church, A., Ludwig, D., Manson, J., Scully, M., Nastouli, E., Chapman, M.D., Hart, M., and Lunn, M.P.
- Subjects
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COVID-19 , *BIOMARKERS , *ADULT respiratory distress syndrome , *CYTOKINE release syndrome , *INTERLEUKIN-6 - Abstract
The heterogeneous disease course of COVID-19 is unpredictable, ranging from mild self-limiting symptoms to cytokine storms, acute respiratory distress syndrome (ARDS), multi-organ failure and death. Identification of high-risk cases will enable appropriate intervention and escalation. This study investigates the routine laboratory tests and cytokines implicated in COVID-19 for their potential application as biomarkers of disease severity, respiratory failure and need of higher-level care. From analysis of 203 samples, CRP, IL-6, IL-10 and LDH were most strongly correlated with the WHO ordinal scale of illness severity, the fraction of inspired oxygen delivery, radiological evidence of ARDS and level of respiratory support (p ≤ 0.001). IL-6 levels of ≥3.27 pg/ml provide a sensitivity of 0.87 and specificity of 0.64 for a requirement of ventilation, and a CRP of ≥37 mg/l of 0.91 and 0.66. Reliable stratification of high-risk cases has significant implications on patient triage, resource management and potentially the initiation of novel therapies in severe patients. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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