1. G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan
- Author
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Lin, Ying-Ju, Wan, Lei, Sheu, Jim Jinn-Chyuan, Huang, Chung-Ming, Lin, Cheng-Wen, Lan, Yu-Ching, Lai, Chih-Ho, Hung, Chien-Hui, Tsai, Yuhsin, Tsai, Chang-Hai, Lin, Wei-Yong, Liu, Hsin-Ping, Lin, Ting-Hsu, Huang, Yu-Min, and Tsai, Fuu-Jen
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GENETIC polymorphisms , *INTERLEUKIN-2 , *EXONS (Genetics) , *SYSTEMIC lupus erythematosus , *CYTOKINES , *T cells , *PATIENTS - Abstract
Abstract: Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P =1.91×10−14; OR=3.94; 95% CI=2.74–5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P =0.033; OR=4.21; 95% CI=1.01–17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P =0.019; OR=0.41; 95% CI=0.19–0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. [Copyright &y& Elsevier]
- Published
- 2008
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