1. Thymic function in NZB mice
- Author
-
M.A. Bach, P. Bardos, and Y. Lebranchu
- Subjects
medicine.medical_specialty ,Immunology ,chemical and pharmacologic phenomena ,Endogeny ,Spleen ,Biology ,Pathology and Forensic Medicine ,law.invention ,Immune system ,immune system diseases ,law ,Sex factors ,Internal medicine ,medicine ,Immunology and Allergy ,Secretion ,Chemistry ,Nk activity ,Half-life ,Facteur Thymique Serique ,Serum Thymic Factor ,medicine.anatomical_structure ,Antibody response ,Endocrinology ,Suppressor ,Function (biology) - Abstract
Adult NZB mice which lack endogenous circulating thymic factor have been treated with synthetic facteur thymique serique (FTS) or grafted by H-2-compatible newborn thymus grafts and tested for susceptibility of their primary anti-SRBC antibody response to suppression induced by SRBC-sensitized spleen cells. Whereas anti-SRBC antibody response of control NZB recipient mice of both sexes was poorly suppressed by immune splenic suppressor cells, susceptibility to suppression was increased in FTS-treated or thymus-grafted male recipient NZB mice. Both FTS itself and a structural analog chosen for its prolonged half life in the serum, and used at lower dose, were efficient. Syngeneic newborn thymus graft but not DBA 2 newborn thymus graft was similarly active in restoring susceptibility to suppression. All these treatments failed to increase sensitivity to suppression in female NZB mice.
- Published
- 1982