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2 results on '"Ferlito, Claudia"'

1. Anti-polysaccharide and anti-diphtheria protective antibodies after 13-valent pneumococcal conjugate vaccination in rheumatoid arthritis patients under immunosuppressive therapy.

Author

Caporuscio S, Ieraci R, Valesini G, Teloni R, Mariotti S, Spinelli FR, Ferlito C, Salemi S, Picchianti Diamanti A, Meneguzzi G, Markovic M, Sgrulletti M, von Hunolstein C, Ralli L, Pinto A, Salerno G, Canzoni M, Sorgi ML, Laganà B, Di Rosa R, Nisini R, and D'Amelio R

Subjects
Aged, Antibodies, Bacterial blood, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid epidemiology, Female, Humans, Immunity, Humoral, Immunocompromised Host, Immunoglobulin G blood, Immunosuppressive Agents therapeutic use, Italy epidemiology, Male, Middle Aged, Pneumococcal Infections epidemiology, Polysaccharides, Bacterial immunology, Vaccination, Arthritis, Rheumatoid immunology, Corynebacterium diphtheriae physiology, Diphtheria immunology, Pneumococcal Infections immunology, Pneumococcal Vaccines immunology
Abstract

Immunogenicity of 13-valent pneumococcal polysaccharide (PnPS) conjugate vaccine (PCV13) was evaluated in 38 rheumatoid arthritis patients under immunosuppressive treatment and 20 healthy controls (HC). Antibodies to all PnPS and diphtheria-toxin analogue conjugate protein were measured pre- (T0), 1 (T1), 6 (T2), 12 (T3) months post-immunization. Patients and HC had similar response to individual PnPS. Mean antibody levels to all PnPS but one doubled at T1 compared with T0, with T3 persistence for only 8-7/13 PnPS. Baseline antibody levels was inversely associated with the rate of responders at T1 (T1/T0≥2) to 11/13 PnPS. Few subjects reached protective IgG levels against some serotypes frequently isolated in Italian patients with invasive pneumococcal disease. Antibody response was not influenced by therapy, except the one to PS7F, which was reduced by tumor necrosis factor-α-inhibitors. Vaccination increased also anti-diphtheria IgG. Despite this study substantially confirmed the PCV13 immunogenicity in immunocompromised patients, it also revealed some limitations., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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2. Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel.

Author

Ferlito C, Barnaba V, Abrignani S, Bombaci M, Sette A, Sidney J, Biselli R, Tomao E, Cattaruzza MS, Germano V, Biondo MI, Salerno G, Lulli P, Caporuscio S, Picchianti Diamanti A, Falco M, Biselli V, Cardelli P, Autore A, Lucertini E, De Cesare DP, Peragallo MS, Lista F, Martire C, Salemi S, Nisini R, and D'Amelio R

Subjects
Adolescent, Adult, Antibodies, Antineutrophil Cytoplasmic immunology, Antibodies, Antinuclear immunology, Antibodies, Antiphospholipid immunology, Autoantibodies immunology, Autoimmune Diseases immunology, Blood Protein Electrophoresis, Chickenpox Vaccine therapeutic use, Diphtheria-Tetanus Vaccine therapeutic use, Female, Follow-Up Studies, Hepatitis A Vaccines therapeutic use, Hepatitis B Vaccines therapeutic use, Humans, Immunoglobulins blood, Influenza Vaccines therapeutic use, Italy epidemiology, Lymphoproliferative Disorders immunology, Male, Measles-Mumps-Rubella Vaccine therapeutic use, Meningococcal Vaccines therapeutic use, Poliovirus Vaccine, Inactivated therapeutic use, Prospective Studies, Rheumatoid Factor immunology, Risk Factors, Typhoid-Paratyphoid Vaccines therapeutic use, Young Adult, Autoimmune Diseases epidemiology, Lymphoproliferative Disorders epidemiology, Military Personnel statistics & numerical data, Vaccines therapeutic use
Abstract

Anecdotal case reports, amplified by mass media and internet-based opinion groups, have recently indicated vaccinations as possibly responsible for autoimmunity/lymphoproliferation development. Multiply vaccinated Italian military personnel (group 1, operating in Italy, group 2, operating in Lebanon) were followed-up for nine months to monitor possible post-vaccine autoimmunity/lymphoproliferation onset. No serious adverse event was noticed in both groups. Multivariate analysis of intergroup differences only showed a significant association between lymphocyte increase and tetanus/diphtheria vaccine administration. A significant post-vaccine decrease in autoantibody positivity was observed. Autoantibodies were also studied by microarray analysis of self-proteins in subjects exposed to ≥4 concurrent vaccinations, without observing significant difference among baseline and one and nine months post-vaccine. Moreover, HLA-A2 subjects have been analyzed for the possible CD8T-cell response to apoptotic self-epitopes, without observing significant difference between baseline and one month post-vaccine. Multiple vaccinations in young adults are safe and not associated to autoimmunity/lymphoproliferation onset during a nine-month-long follow-up., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2017
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