1. Accelerated and Enhanced Bone Formation on Novel Simvastatin-Loaded Porous Titanium Oxide Surfaces
- Author
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Shohei Kasugai, Reena Rodriguez, Myat Nyan, Takayuki Miyahara, Jia Hao, and Kanako Noritake
- Subjects
business.industry ,Oxide ,chemistry.chemical_element ,Dentistry ,Osseointegration ,Titanium oxide ,Apposition ,chemistry.chemical_compound ,chemistry ,Simvastatin ,medicine ,Implant ,Oral Surgery ,Bone regeneration ,business ,General Dentistry ,Titanium ,medicine.drug - Abstract
Background With increasing application of dental implants in poor-quality bones, the need for implant surfaces ensuring accelerated osseointegration and enhanced peri-implant bone regeneration is increased. Purpose A study was performed to evaluate the osseointegration and bone formation on novel simvastatin-loaded porous titanium oxide surface. Materials and Methods Titanium screws were treated by micro-arc oxidation to form porous oxide surface and 25 or 50 μg of simvastatin was loaded. The nontreated control, micro-arc oxidized, and simvastatin-loaded titanium screws were surgically implanted into the proximal tibia of 16-week-old male Wistar rats (n = 36). Peri-implant bone volume, bone-implant contact, and mineral apposition rates were measured at 2 and 4 weeks. Data were analyzed by one-way analysis of variance followed by Tukey's post hoc test. Results New bone was formed directly on the implant surface in the bone marrow cavity in simvastatin-loaded groups since 2 weeks. Bone-implant contact values were significantly higher in simvastatin-loaded groups than control and micro-arc oxidized groups at both time points (p
- Published
- 2013