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Your search keyword '"Andrew Bosworth"' showing total 2 results
Start Over Author "Andrew Bosworth" Journal clinical infection in practice
2 results on '"Andrew Bosworth"'

1. Letermovir salvage therapy in the management of a case of cytomegalovirus ventriculitis complicated by drug resistance

Author

Andrew Bosworth, Sowsan F. Atabani, Anastasia Theodosiou, Avneet Shahi, Tatiana Peate, Steven Wilson, Emanuela Pelosi, and Andrew Rosser

Subjects
Cytomegalovirus, Drug resistance, Letermovir, Immunocompromised, Human immunodeficiency virus, Clinical virology, Infectious and parasitic diseases, RC109-216
Abstract

Reported is a case of cytomegalovirus ventriculitis on a background of HIV infection. Sequencing demonstrated viral mutations conferring resistance to available therapies. Compassionate use of letermovir was attempted; though clinical improvement was observed the patient passed away. Sequencing demonstrated that known letermovir resistance mutations were not detected in this virus.

Published
2020
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2. Letermovir salvage therapy in the management of a case of cytomegalovirus ventriculitis complicated by drug resistance

Author

Tatiana Peate, Avneet K. Shahi, Andrew Bosworth, Steven Wilson, Emanuela Pelosi, Anastasia Theodosiou, Andrew J Rosser, and Sowsan F Atabani

Subjects
Clinical virology, Human immunodeficiency virus, business.industry, Congenital cytomegalovirus infection, Human immunodeficiency virus (HIV), Cytomegalovirus, Salvage therapy, Compassionate Use, General Medicine, Drug resistance, medicine.disease, medicine.disease_cause, Virology, Virus, lcsh:Infectious and parasitic diseases, Letermovir, Ventriculitis, Medicine, lcsh:RC109-216, business, Immunocompromised, medicine.drug
Abstract

Reported is a case of cytomegalovirus ventriculitis on a background of HIV infection. Sequencing demonstrated viral mutations conferring resistance to available therapies. Compassionate use of letermovir was attempted; though clinical improvement was observed the patient passed away. Sequencing demonstrated that known letermovir resistance mutations were not detected in this virus.

Published
2020
Full Text
View/download PDF

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