1. Transcontinental Dissemination of the L2b/D-Da Recombinant Chlamydia trachomatis Lymphogranuloma venereum (LGV) Strain: Need of Broad Multi-Country Molecular Surveillance
- Author
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Haim Paran, Israel Nissan, Cândida Fernandes, Jennifer Beirnes, Cristina Belo Correia, Miguel Rocha, Gal Wagner-Kolasko, Zohra Lodhia, Maria José Borrego, Cristina Toscano, Zeev Dveyrin, Jacinta Azevedo, Alberto Severini, Efrat Rorman, Rita Côrte-Real, Joana Isidro, Maria Ana Pessanha, Shlomo Pilo, Vítor Borges, Luís Vieira, Yossi Paitan, Joao Alves, João Paulo Gomes, Ana Maria Rodrigues, Dora Cordeiro, João Roxo, and Suzanne Gibbons
- Subjects
Microbiology (medical) ,Lymphogranuloma Venereum (LGV) ,Chlamydia trachomatis ,urologic and male genital diseases ,medicine.disease_cause ,DNA sequencing ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Antibiotic resistance ,law ,Genotype ,Fluoroquinolones Resistance ,Medicine ,Infecções Sexualmente Transmissíveis ,030212 general & internal medicine ,030505 public health ,Resistência aos Antimicrobianos ,business.industry ,Strain (biology) ,Lymphogranuloma venereum ,bacterial infections and mycoses ,medicine.disease ,Virology ,Recombination ,female genital diseases and pregnancy complications ,Infectious Diseases ,Intercontinental Dissemination ,Recombinant DNA ,0305 other medical science ,business ,Multi country - Abstract
Previously, we identified a Chlamydia trachomatis Lymphogranuloma venereum (LGV) recombinant strain possessing a unique non-LGV ompA genotype. Here, culture-independent genome sequencing confirms its circulation in Europe, Middle East and North America, and unveils genetic evidence of emergence of antibiotic resistance. Multi-country and systematic molecular surveillance is needed. This work results in part from the GenomePT project (POCI-01–0145-FEDER-022184), supported by COMPETE 2020— Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT). This work was also supported by Fundos FEDER through the Programa Operacional Factores de Competitividade—COMPETE and by Fundos Nacionais through the Fundação para a Ciência e a Tecnologia within the scope of the project UID/BIM/00009/2019 (Centre for Toxicogenomics and Human Health -ToxOmics). info:eu-repo/semantics/publishedVersion
- Published
- 2021
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