1. Trends in Bloodstream Infections among Human Immunodeficiency Virus–Infected Adults Admitted to a Hospital in Nairobi, Kenya, during the Last Decade
- Author
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Charles F. Gilks, J. Kimari, Videlis N. Nduba, Samuel Kariuki, Gilly Arthur, and S M Bhatt
- Subjects
Adult ,Male ,Microbiology (medical) ,medicine.medical_specialty ,Tuberculosis ,AIDS-Related Opportunistic Infections ,Prevalence ,Bacteremia ,medicine.disease_cause ,Patient Admission ,Acquired immunodeficiency syndrome (AIDS) ,Internal medicine ,Streptococcus pneumoniae ,medicine ,Humans ,Prospective Studies ,Survival rate ,Fungemia ,business.industry ,Mycobacterium tuberculosis ,medicine.disease ,Kenya ,Hospitalization ,Cross-Sectional Studies ,Infectious Diseases ,Immunology ,Cryptococcus neoformans ,Female ,business - Abstract
Bloodstream infections are a frequent complication in human immunodeficiency virus (HIV)-infected adults in Africa and usually associated with a poor prognosis. We evaluated bloodstream infections across a decade in 3 prospective cross-sectional surveys of consecutive medical admissions to the Kenyatta National Hospital, Nairobi, Kenya. Participants received standard clinical care throughout. In 1988-1989, 29.5% (28 of 95) of HIV-positive patients had bloodstream infections, compared with 31.9% (46 of 144) in 1992 and 21.3% (43 of 197) in 1997. Bacteremia and mycobacteremia were significantly associated with HIV infection. Infections with Mycobacterium tuberculosis, non-typhi species of Salmonella (NTS), and Streptococcus pneumoniae predominated. Fungemia exclusively due to Cryptococcus neoformans was uncommon. Clinical features at presentation remained similar. Significant improvements in the survival rate were recorded among patients with NTS bacteremia (20%-83%; P
- Published
- 2001
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