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Start Over Author "Schuster, Gertrud" Journal clinical infectious diseases
4 results on '"Schuster, Gertrud"'

1. Vitamin D3 Supplementation Increases Spine Bone Mineral Density in Adolescents and Young Adults With Human Immunodeficiency Virus Infection Being Treated With Tenofovir Disoproxil Fumarate: A Randomized, Placebo-Controlled Trial

Author

Havens, Peter L, Stephensen, Charles B, Van Loan, Marta D, Schuster, Gertrud U, Woodhouse, Leslie R, Flynn, Patricia M, Gordon, Catherine M, Pan, Cynthia G, Rutledge, Brandy, Harris, D Robert, Price, Georgine, Baker, Alyne, Meyer, William A, Wilson, Craig M, Hazra, Rohan, Kapogiannis, Bill G, Mulligan, Kathleen, Vellala, Kavya, Wheeler, Justin, Fielding, Roger, Freytag, Tammy, Domek, Joseph, Gertz, Erik, Emmanuel, Patricia, Straub, Diane, Enriquez-Bruce, Elizabeth, Belzer, Marvin, Tucker, Diane, D’Angelo, Larry, Trexler, Connie, Douglas, Steve, Tanney, Mary, Stroger, John H, Martinez, Miguel, Henry-Reid, Lisa, Bojan, Kelly, Futterman, Donna, Campos, Maria, Abdalian, Sue Ellen, Kozina, Leslie, Friedman, Larry, Maturo, Donna, Flynn, Pat, Guar, Aditya, Dillard, Mary, Paul, Mary, Head, Jane, Secord, Liz, Outlaw, Angulique, Cromer, Charnell, Agwu, Allison, Sanders, Renata, Anderson, Thuy, Mayer, Ken, Dormitzer, Julian, Reirden, Dan, Chambers, Carrie, Kovacs, Andrea, Operskalski, Eva, Homans, James, Bearden, Allison, Sanchez, Susie, Puga, Ana, Eysallenne, Zulma, Acevedo, Midnela, Rosario, Nicolas, Nieves, Lourdes Angeli, Wiznia, Andrew, Abadi, Jacobo, Rosenberg, Michael, Dobroszycki, Joanna, and Burey, Marlene

Subjects
Prevention, Clinical Trials and Supportive Activities, Clinical Research, Complementary and Integrative Health, Nutrition, Pediatric, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adolescent, Anti-HIV Agents, Bone Density, Bone Density Conservation Agents, Calcium-Regulating Hormones and Agents, Cholecalciferol, Double-Blind Method, Female, HIV Infections, Humans, Male, Placebos, Spine, Tenofovir, Treatment Outcome, Young Adult, tenofovir disoproxil fumarate, vitamin D supplementation, bone mineral density, parathyroid hormone, HIV infection, Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) 109 Study Team, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundTenofovir disoproxil fumarate (TDF) decreases bone mineral density (BMD). We hypothesized that vitamin D3 (VITD3) would increase BMD in youth receiving TDF.MethodsThis was a randomized, double-blind, placebo-controlled trial of directly observed VITD3 vs placebo every 4 weeks for 48 weeks in youth aged 16-24 years with HIV, RNA load

Published
2018

2. Decline in Bone Mass With Tenofovir Disoproxil Fumarate/Emtricitabine Is Associated With Hormonal Changes in the Absence of Renal Impairment When Used by HIV-Uninfected Adolescent Boys and Young Men for HIV Preexposure Prophylaxis.

Author

Havens, Peter L, Stephensen, Charles B, Van Loan, Marta D, Schuster, Gertrud U, Woodhouse, Leslie R, Flynn, Patricia M, Gordon, Catherine M, Pan, Cynthia G, Rutledge, Brandy, Liu, Nancy, Wilson, Craig M, Hazra, Rohan, Hosek, Sybil G, Anderson, Peter L, Seifert, Sharon M, Kapogiannis, Bill G, and Mulligan, Kathleen

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, HIV/AIDS, Prevention, Osteoporosis, Clinical Trials and Supportive Activities, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Musculoskeletal, Good Health and Well Being, Adolescent, Anti-HIV Agents, Bone Density, Creatinine, Emtricitabine, Fibroblast Growth Factor-23, Glomerular Filtration Rate, HIV Infections, Homosexuality, Male, Humans, Kidney, Male, Parathyroid Hormone, Pre-Exposure Prophylaxis, Renal Insufficiency, Tenofovir, Young Adult, tenofovir disoproxil fumarate, bone mineral density, parathyroid hormone, fibroblast growth factor 23, HIV pre-exposure prophylaxis, Adolescent Medicine Trials Network for HIV/AIDS Interventions 117 study team, HIV pre- exposure prophylaxis., Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundWe aimed to define the relative importance of renal and endocrine changes in tenofovir disoproxil fumarate (TDF)-related bone toxicity.MethodsIn a study of daily TDF/emtricitabine (FTC) preexposure prophylaxis (PrEP) in human immunodeficiency virus (HIV)-uninfected young men who have sex with men, we measured changes from baseline in blood and urine markers of the parathyroid hormone (PTH)-vitamin D-fibroblast growth factor 23 (FGF23) axis, creatinine, and renal tubular reabsorption of phosphate (TRP). We explored the relationship of those variables to changes in bone mineral density (BMD). Tenofovir-diphosphate (TFV-DP) in red blood cells was used to categorize participants into high and low drug exposure groups.ResultsThere were 101 participants, median age 20 years (range 15 to 22). Compared with low drug exposure, high-exposure participants showed increase from baseline in PTH and decline in FGF23 by study week 4, with no differences in creatinine, phosphate, or TRP. At 48 weeks, the median (interquartile range) percent decline in total hip BMD was greater in those with high- compared to low- exposure (-1.59 [2.77] vs +1.54 [3.34] %, respectively; P = .001); in high-exposure participants, this correlated with week 4 TFV-DP (inversely; r = -0.60, P = .002) and FGF23 (directly; r = 0.42; P = .039) but not other variables.ConclusionsThese findings support the short-term renal safety of TDF/FTC PrEP in HIV-seronegative young men and suggest that endocrine disruption (PTH-FGF23) is a primary contributor to TDF-associated BMD decline in this age group.Clinical trials registrationNCT01769469.

Published
2017

3. Vitamin D3 Supplementation Increases Spine Bone Mineral Density in Adolescents and Young Adults With Human Immunodeficiency Virus Infection Being Treated With Tenofovir Disoproxil Fumarate : A Randomized, Placebo-Controlled Trial

Author

Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) 109 Study Team, Havens, Peter L., Stephensen, Charles B., Van Loan, Marta D., Schuster, Gertrud U., Woodhouse, Leslie R., Flynn, Patricia M., Gordon, Catherine M., Pan, Cynthia G., Rutledge, Brandy, Harris, D. Robert, Price, Georgine, Baker, Alyne, Meyer, William A., Wilson, Craig M., Hazra, Rohan, Kapogiannis, Bill G., and Mulligan, Kathleen

Published
2018

4. Decline in Bone Mass With Tenofovir Disoproxil Fumarate/Emtricitabine Is Associated With Hormonal Changes in the Absence of Renal Impairment When Used by HIV-Uninfected Adolescent Boys and Young Men for HIV Preexposure Prophylaxis

Author

Adolescent Medicine Trials Network for HIV/AIDS Interventions 117 study team, Havens, Peter L., Stephensen, Charles B., Van Loan, Marta D., Schuster, Gertrud U., Woodhouse, Leslie R., Flynn, Patricia M., Gordon, Catherine M., Pan, Cynthia G., Rutledge, Brandy, Liu, Nancy, Wilson, Craig M., Hazra, Rohan, Hosek, Sybil G., Anderson, Peter L., Seifert, Sharon M., Kapogiannis, Bill G., and Mulligan, Kathleen

Published
2017

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