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Your search keyword '"Zhong Lina"' showing total 5 results
Start Over Author "Zhong Lina" Journal clinical infectious diseases
5 results on '"Zhong Lina"'

1. Gut resistome of preschool children after prolonged mass azithromycin distribution: a cluster-randomized trial

Author

Arzika, Ahmed M, Maliki, Ramatou, Abdou, Amza, Mankara, Alio K, Harouna, Abdoul N, Cook, Catherine, Hinterwirth, Armin, Worden, Lee, Zhong, Lina, Chen, Cindi, Ruder, Kevin, Zhou, Zhaoxia, Lebas, Elodie, O’Brien, Kieran S, Oldenburg, Catherine E, Le, Victoria, Arnold, Benjamin F, Porco, Travis, Keenan, Jeremy D, Lietman, Thomas M, and Doan, Thuy

Subjects
Clinical Trials and Supportive Activities, Pediatric, Antimicrobial Resistance, Clinical Research, Anti-Bacterial Agents, Azithromycin, Child, Preschool, Drug Resistance, Bacterial, Humans, Macrolides, Mass Drug Administration, azithromycin, antibiotic resistance, gut resistome, mass drug distribution, Niger, preschool children, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs.Clinical trials registrationNCT02047981.

Published
2021

2. Reduction of coronavirus burden with mass azithromycin distribution

Author

Doan, Thuy, Hinterwirth, Armin, Arzika, Ahmed M, Worden, Lee, Chen, Cindi, Zhong, Lina, Oldenburg, Catherine E, Keenan, Jeremy D, and Lietman, Thomas M

Subjects
Clinical Research, Lung, Emerging Infectious Diseases, Clinical Trials and Supportive Activities, 5.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Development of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Administration, Oral, Antiviral Agents, Azithromycin, Child, Preschool, Coronavirus, Coronavirus Infections, Humans, Infant, Infant, Newborn, Mass Drug Administration, Nasopharynx, Nigeria, Viral Load, azithromycin, coronavirus, children, virome, Niger, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

We evaluated the potential antiviral effects of azithromycin on the nasopharyngeal virome of Nigerien children who had received multiple rounds of mass drug administration. We found that the respiratory burden of non-severe acute respiratory syndrome coronaviruses was decreased with azithromycin distributions. Clinical Trials Registration. NCT02047981.

Published
2020

3. Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial.

Author

Oldenburg, Catherine E, Hinterwirth, Armin, Sié, Ali, Coulibaly, Boubacar, Ouermi, Lucienne, Dah, Clarisse, Tapsoba, Charlemagne, Cummings, Susie L, Zhong, Lina, Chen, Cindi, Sarkar, Samarpita, Bärnighausen, Till, Lietman, Thomas M, Keenan, Jeremy D, and Doan, Thuy

Subjects
Pediatric, Clinical Research, Antimicrobial Resistance, Infectious Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Anti-Bacterial Agents, Azithromycin, Burkina Faso, Child, Preschool, Gastrointestinal Microbiome, Humans, Infant, Macrolides, resistome, antimicrobial resistance, randomized controlled trial, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.

Published
2020

5. Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial

Author

Oldenburg, Catherine E, primary, Hinterwirth, Armin, additional, Sié, Ali, additional, Coulibaly, Boubacar, additional, Ouermi, Lucienne, additional, Dah, Clarisse, additional, Tapsoba, Charlemagne, additional, Cummings, Susie L, additional, Zhong, Lina, additional, Chen, Cindi, additional, Sarkar, Samarpita, additional, Bärnighausen, Till, additional, Lietman, Thomas M, additional, Keenan, Jeremy D, additional, and Doan, Thuy, additional

Published
2019
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