1. Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort.
- Author
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Mills TC, Chapman S, Hutton P, Gordon AC, Bion J, Chiche JD, Holloway PA, Stüber F, Garrard CS, Hinds CJ, Hill AV, and Rautanen A
- Subjects
- Adult, Cohort Studies, Female, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide genetics, Genetic Predisposition to Disease genetics, Mannose-Binding Lectin genetics, Sepsis epidemiology, Sepsis genetics
- Abstract
Background: Sepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from, sepsis for variants in the functionally important immune-related gene MBL2. These studies have largely been underpowered and contradictory., Methods: We genotyped and analyzed 4 important MBL2 single nucleotide polymorphisms (SNPs; rs5030737, rs1800450, rs1800451, and rs7096206) in 1839 European community-acquired pneumonia (CAP) and peritonitis sepsis cases, and 477 controls from the United Kingdom. We analyzed the following predefined subgroups and outcomes: 28-day and 6 month mortality from sepsis due to CAP or peritonitis combined, 28-day mortality from CAP sepsis, peritonitis sepsis, pneumococcal sepsis or sepsis in younger patients, and susceptibility to CAP sepsis or pneumococcal sepsis in the United Kingdom., Results: There were no significant associations (all P-values were greater than .05 after correction for multiple testing) between MBL2 genotypes and any of our predefined analyses., Conclusions: In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified., (© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.)
- Published
- 2015
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