1. A seronegative case of HIV-1 subtype C infection in Botswana.
- Author
-
Novitsky V, Gaolathe T, Woldegabriel E, Makhema J, and Essex M
- Subjects
- Botswana, False Negative Reactions, Fatal Outcome, Female, HIV Antibodies blood, HIV Infections complications, HIV Infections diagnosis, HIV-1 genetics, Humans, Middle Aged, AIDS Serodiagnosis, HIV Antibodies immunology, HIV Infections immunology, HIV-1 immunology, RNA, Viral blood
- Abstract
We report the first case, to our knowledge, of antibody-negative human immunodeficiency virus type 1 (HIV-1) subtype C infection, which was identified during screening for acute HIV-1 infection in Botswana. Results of tests for HIV-1 antibodies were consistently negative, including rapid and regular enzyme-linked immunosorbent assay and Western blot. The nonrecombinant HIV-1 subtype C infection was confirmed by viral genotyping within the gag, pol, and env genes. The period between referral of the patient in a clinically stable condition and AIDS-related death was approximately 3 months. The reported case indicates the importance of studying the prevalence of seronegative HIV-1 infection in southern Africa, where subtype C predominates.
- Published
- 2007
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