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1. Inhibition of clonal expansion of parietal epithelial cells and crescent–podocyte transition in severe glomerulonephritis: on the way to targeted therapy?

Author

Mentese, Ilay Berke and Kronbichler, Andreas

Subjects
*BORTEZOMIB, *PARIETAL cells, *EPITHELIAL cells, *LUPUS nephritis, *MYELOFIBROSIS, *GLOMERULONEPHRITIS, *STEM cell niches
Abstract

The human kidney possesses progenitor cells in the glomerular and tubular compartments of the nephron, capable of self-renewal, proliferation and differentiation. Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice. The crescent-forming PEC subset in humans was found to be characterized by expression of CD133, a marker of renal progenitor cells, and stratifin, a cell cycle checkpoint protein involved in stem cell proliferation/differentiation. [Extracted from the article]

Published
2023
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