1. Live Birth from Previously Vitrified Oocytes, After Trophectoderm Biopsy, Revitrification, and Transfer of a Euploid Blastocyst
- Author
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Santiago Munné, E. Ampeloquio, Brooke Hodes-Wertz, Alan S. Berkeley, Alexis Adler, Jamie Grifo, Melicia Clarke-Williams, and Hsiao Ling Lee
- Subjects
Cultural Studies ,Infertility ,Linguistics and Language ,History ,fertility preservation ,Case Report ,Preimplantation genetic diagnosis ,lcsh:Gynecology and obstetrics ,Language and Linguistics ,Andrology ,medicine ,Fertility preservation ,Blastocyst ,preimplantation genetic diagnosis ,lcsh:RG1-991 ,business.industry ,lcsh:Public aspects of medicine ,oocyte cryopreservation ,Preimplantation Screening ,lcsh:RA1-1270 ,Oocyte cryopreservation ,Oocyte ,medicine.disease ,medicine.anatomical_structure ,Anthropology ,array comparative genomic hybridization ,embryonic structures ,embryo biopsy ,Live birth ,business ,trophectoderm biopsy ,Biomedical engineering - Abstract
Our objective is to describe a successful live birth from oocyte vitrification followed by thaw, fertilization, blastocyst culture, trophectoderm biopsy, vitrification, and subsequent thaw. Fifteen mature oocytes were frozen from a patient with uterine factor infertility. Thirteen oocytes survived the thaw, and five underwent trophectoderm biopsy and were refrozen. Three euploid embryos were obtained. A single euploid embryo was transferred in the second thaw cycle to a known recipient leading to the delivery of a normal male infant. This case report is proof of the concept that preimplantation screening and diagnosis is an option for fertility preservation patients.
- Published
- 2013