1. Mucormycosis in Australia: contemporary epidemiology and outcomes
- Author
-
C.L. Halliday, Sau-Chin Chen, Tania C. Sorrell, Sarah E. Kidd, Karina Kennedy, C. Blyth, C.H. Heath, Christopher C Blyth, Tony M. Korman, R. Beresford, David Looke, Christopher H. Heath, Michelle Ananda-Rajah, S. Kidd, Narin Bak, Catriona Halliday, Brendan McMullan, Wieland Meyer, Kathryn Daveson, Monica A. Slavin, Elaine Y-L Cheong, Joseph G. McCormack, Eugene Athan, Arthur J. Morris, Steve Chambers, Weiland Meyer, C. Orla Morrissey, Monica A Slavin, E. Geoffrey Playford, Krispin Hajkowicz, Deborah Marriott, Deborrah J Marriott, Sebastian Van Hal, S. J. van Hal, Sharon C.-A. Chen, T.C. Sorrell, Belinda Chapman, Andie S Lee, Ian Arthur, Julia E Clark, J.O. Robinson, C. O. Morrissey, Thomas Gottlieb, N. Bak, and K. Daveson
- Subjects
Adult ,Male ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Adolescent ,030106 microbiology ,Comorbidity ,law.invention ,Saksenaea ,Young Adult ,03 medical and health sciences ,law ,Internal medicine ,Epidemiology ,medicine ,Humans ,Mucormycosis ,Aged ,Retrospective Studies ,biology ,business.industry ,Australia ,Disease Management ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,biology.organism_classification ,Intensive care unit ,Surgery ,Patient Outcome Assessment ,Infectious Diseases ,Female ,Disease Susceptibility ,Zygomycosis ,business ,Apophysomyces - Abstract
Mucormycosis is the second most common cause of invasive mould infection and causes disease in diverse hosts, including those who are immuno-competent. We conducted a multicentre retrospective study of proven and probable cases of mucormycosis diagnosed between 2004-2012 to determine the epidemiology and outcome determinants in Australia. Seventy-four cases were identified (63 proven, 11 probable). The majority (54.1%) were caused by Rhizopus spp. Patients who sustained trauma were more likely to have non-Rhizopus infections relative to patients without trauma (OR 9.0, p 0.001, 95% CI 2.1-42.8). Haematological malignancy (48.6%), chemotherapy (42.9%), corticosteroids (52.7%), diabetes mellitus (27%) and trauma (22.9%) were the most common co-morbidities or risk factors. Rheumatological/autoimmune disorders occurred in nine (12.1%) instances. Eight (10.8%) cases had no underlying co-morbidity and were more likely to have associated trauma (7/8; 87.5% versus 10/66; 15.2%; p
- Published
- 2016
- Full Text
- View/download PDF