1. Voriconazole-Induced Periostitis After Allogeneic Stem Cell Transplantation.
- Author
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Haemels M, Pans S, Schoemans H, Goffin K, Gheysens O, and Jentjens S
- Subjects
- Adult, Hodgkin Disease therapy, Humans, Male, Periostitis diagnostic imaging, Single Photon Emission Computed Tomography Computed Tomography, Antifungal Agents adverse effects, Periostitis chemically induced, Stem Cell Transplantation, Voriconazole adverse effects
- Abstract
A 34-year-old man with history of Hodgkin lymphoma presented 7 months after allogeneic stem cell transplantation with an unexplained severe musculoskeletal pain syndrome. A Tc-MDP bone SPECTCT showed multiple foci with moderate to intense bone uptake across the axial and appendicular skeleton consistent with periostitis. The patient had been on voriconazole daily for 4 months to treat an Aspergillus pneumonia, and in the absence of other causes, a drug-induced periostitis was suspected. Voriconazole was changed to posaconazole with complete resolution of the musculoskeletal symptoms within 3 weeks.
- Published
- 2019
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