1. 68Ga-DOTATATE PET/CT Reveals Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma in a Case of Suspected Sphenoid Wing Meningioma.
- Author
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Unterrainer M, Maihoefer C, Cyran CC, Bartenstein P, Niyazi M, and Albert NL
- Subjects
- Adult, Carcinoma complications, Humans, Male, Meningeal Neoplasms complications, Meningioma complications, Nasopharyngeal Carcinoma, Nasopharyngeal Neoplasms complications, Carcinoma diagnostic imaging, Carcinoma virology, Herpesvirus 4, Human physiology, Meningeal Neoplasms diagnosis, Meningioma diagnostic imaging, Nasopharyngeal Neoplasms diagnostic imaging, Nasopharyngeal Neoplasms virology, Organometallic Compounds, Positron Emission Tomography Computed Tomography
- Abstract
In this case of suspected sphenoid wing meningioma, Ga-DOTATATE PET/CT showed a somatostatin receptor (SSR)-expressing tumor with extension to the nasopharynx and SSR-expressing cervical lymph nodes. Subsequent biopsy from the nasopharynx revealed an Epstein-Barr virus (EBV)-associated, undifferentiated World Health Organization type 3 nasopharyngeal carcinoma (NPC), a potential clinical pitfall due to the reported high SSR expression of this tumor subtype. In consideration of the high target-to-background contrast, SSR ligands might be superior to F-FDG for EBV-associated NPC PET imaging, particularly at the skull base. Somatostatin receptor ligands might furthermore offer interesting theranostic possibilities for patients with advanced/extensive EBV-associated NPC.
- Published
- 2018
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