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International audience; Rationale: Amyotrophic lateral sclerosis (ALS) is a severe neurological disease very often accompanied by malnutrition. Nutritional status and body composition are factors associated with survival. The total body bioelectric impedance analysis (BIA) with a validated equation (Desport et al.) allows to assess the body composition during this disease, but requires the appropriate equipment. Measuring body composition using the four skin folds is simple to perform but not validated in ALS. The aim of our work was to study the agreement of measurements of Fat-Free Mass (FFM) by BIA compared to the skin folds method.Methods: We included all the measurements between 2000 and 2018, for which the ALS patients had a BIA and the measurement of the four skin folds. Skin fold measurements (tricipital, bicipital, subscapular and super-iliac) were performed 3 times on each side and then averaged. The Fat Mass (FM) obtained from the formula of Siri and Durnin & Womersley, allowed us to obtain the FFMsf (weight minus FM). The BIA was performed at 50 kHz. The FFMimp in BIA was calculated using the validated equation of Desport et al. also requiring the measurement of the tricipital skin fold. The correlation between the two methods was evaluated by linear regression and the agreement by the Bland-Altman method.Results: 1045 measurements were studied. The mean age of the patients was 65.0 ± 11.6 years and the sex ration M / F ratio was of 1.1. In BIA, the mean FFMimp was of 46.1 ± 9.1 kg and FFMsf of 44.5 ± 9.3 kg. There was a good correlation between the two methods (R = 0.91, p

International audience; Rationale: Amyotrophic lateral sclerosis (ALS) is a rare disease with a poor prognosis. Body composition is a prognostic factor for survival. During ALS, body composition can be assessed by total body biolelectric impedancemetry analysis (BIA) using a validated reference formula (Desport et al.). This formula is more complex to use than the direct measurement obtained by a BIA device. The aim of the study was to compare the agreement for the Fat-Free Mass (FFM) obtained by BIA with reference formula or with the formula of the device.Methods: The data from January 2015 to January 2019, were extracted from our database and from the BIA devise Bodystat Quadscan 4000® used in consultation. Each ALS patient had a measurement of FFM (FFM) by direct measurement of the device (FFMdev) and by the reference formula (FFMref) also requiring the measurement of the tricipital skin fold. A simple regression test was applied between the two values of FFM and the agreement was determined using the method of Bland and Altman. The repeatability coefficient was studied for the impedance at 50 kHz, from 6 consecutive measurements in 15 patients.Results: The study population included 343 ALS patients. The mean age was of 66.5 years ± 11.0 years, the male / female sex ratio was of 1. The FFMref was of 43.9 ± 9.8 kg and the FFMdev was of 41.7 ± 11.0 kg. The repeatability coefficient of the impedance at 50 kHz was of 0.53 ± 1.28%. The correlation between the two types of measures was very good (R at 0.90, p