1. Vitamin C reduces interleukin-6 plasma concentration: a systematic review and meta-analysis of randomized clinical trials
- Author
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Mohammad Gholizadeh, Said Abdul Ghafour Saeedy, Arash Abdi, Fatemeh Khademi, Keivan Lorian, Cain C.T. Clark, and Kurosh Djafarian
- Subjects
Interleukin 6 ,Vitamin C ,Inflammation ,Cytokine ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Summary: Background: Interleukin 6 is an important biomarker for distinguishing high-risk and low-risk patients, and is a constituent of the Nutrition Risk in the Critically III (NUTRIC) Score. Studies have indicated the beneficial effects of vitamin C on lowering IL-6 levels and reducing cytokine storm. However, there is still controversy about the exact effect, appropriate route, and dose of vitamin C usage. This meta-analysis was conducted to evaluate the current evidence base relating to vitamin C intervention on decreasing IL-6 levels. Methods: A systematic search was performed in PubMed, Scopus, Google Scholar, and Cochran databases, from database inception to July 3rd 2021, to obtain any possible randomized clinical trial for inclusion. After screening and removing unrelated and duplicate articles, 24 eligible articles remained for statistical analysis. Results: We found a significant lowering effect of vitamin C supplementation on IL-6 levels via peroral (PO) (WMD = -0.29 pg/l, 95% CI [-0.42, -0.16], P
- Published
- 2021
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