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To assess, in vitro, variables potentially influencing implant blooming using a human-like imaging phantom and 3D-printed mandibles.Sixty implants were inserted in 3D-printed mandibles in 26 different configurations in order to examine the impact of implant diameter, presence of a cover screw, implant design/material, implant position, and the presence of additional implants on implant blooming using two cone-beam computed tomography (CBCT) devices (Accuitomo [ACC] and NewTom [NWT]). Two observers measured the amount of implant blooming in both buccolingual and mesiodistal directions. Inter-rater agreement and descriptive statistics, grouped by implant characteristic and CBCT device, were calculated.Both CBCT devices increased implant diameter (a mean increase of 9.2% and 11.8% for titanium, 20.3% and 24.4% for zirconium, for ACC and NWT, respectively). An increase in implant diameter did not increase the amount of blooming, whereas placing a cover screw did (from 8.0% to 10.9% for ACC, and from 10.0% to 15.6% for NWT). Moreover, implant design, anatomical region, and the presence of another implant also affected the extent of the blooming.Dental implants show a clear diameter increase on CBCT, with the effect being more pronounced for zirconium than for titanium implants. Similar effects are likely to occur in the clinical setting, potentially masking nonosseointegration, reducing the dimensions of peri-implant defects, and/or causing underestimation of the buccal bone thickness.

To validate in vitro the accuracy of a novel method for bone augmentation of horizontal alveolar bone defects with the help of a surgical guide.Six cone-beam computed tomography scans of patients requiring horizontal bone augmentation were segmented and 3D printed. Two surgeons performed the bone augmentation surgery twice for each case on 3D-printed models, using either a conventional or guided protocol. Each surgeon virtually planned the desired graft shape beforehand. The resulting grafts were compared linearly and volumetrically to the plan; graft density and surgical time were also analyzed.There was significantly less graft volume outside the planned volume with the guided protocol (36.8% ± 14.1 vs. 19.6% ± 12.3, p .01). The use of a guide increased graft accuracy at several measurement points, resulting in less overfill when using the guided protocol (1.7 ± 1.7 mm at the most coronal point, 0.2 mm ± 1.4 at 25%, 0.0 mm ± 0.9 at 50%, 0.1 mm ± 1.1 at 75%, and 0.4 mm ± 1.4 apically). Graft thickness was increased 1 mm coronally from the planned graft (2.8 mm ± 2.3 vs. 1.8 mm ± 2.2, p = .04). Surgical time increased significantly when using a guide (a difference of 2 m 26 s).The technique, tested here in vitro, allows surgeons to improve the accuracy of the resulting graft shape, to better compact material in the coronal portion of the graft, and to reduce the amount of graft material placed outside the planned volume.

OBJECTIVES: The task of this working group was to update the knowledge about the use of drugs and biologicals affecting healing of soft tissue and bone during implant treatment or procedures associated with it. Moreover, the impact of titanium particles and biocorrosion on complications and implant survival has been analysed. MATERIALS AND METHODS: The literature in the areas of interest (platelet concentrates, antiresorptive drugs as well as implant-host interaction) was screened using systematic reviews for the former two areas, whereas a narrative critical review was performed for the latter topic. Two manuscripts on platelet concentrates, one manuscript on antiresorptive drugs and one manuscript on the effects of biocorrosion, were presented for group analysis with subsequent discussion in the plenum and final consensus approval. RESULTS: Results and conclusions of the individual reviews of the three topics are presented in the respective papers. Conclusions of the group on strengths and weaknesses of available evidence as well as consensus statements and directions for further research are provided in this study. The following papers were subject to group discussions and formed the basis for the consensus statements: Stähli A, Strauss FJ, Gruber R. () The use of platelet-rich-plasma to enhance the outcomes of implant-related therapies: a systematic review Strauss FJ, Stähli A, Gruber R. (2018) The use of platelet-rich-fibrin to enhance the outcomes of implant-related therapies: a systematic review Mombelli A, Hashim D, Cionca N. () What is the impact of titanium particles and bio-corrosion on implant survival and complications? A critical review Stavropoulos A, Bertl K, Pietschmann P, Pandis N, Morten Schiødt, Klinge B. () The effect of antiresorptive drugs on implant therapy: a systematic review. ispartof: CLINICAL ORAL IMPLANTS RESEARCH vol:29 pages:93-99 ispartof: location:SWITZERLAND, Pfaffikon status: published

The task of this working group was to update the knowledge about the use of drugs and biologicals affecting healing of soft tissue and bone during implant treatment or procedures associated with it. Moreover, the impact of titanium particles and biocorrosion on complications and implant survival has been analysed.The literature in the areas of interest (platelet concentrates, antiresorptive drugs as well as implant-host interaction) was screened using systematic reviews for the former two areas, whereas a narrative critical review was performed for the latter topic. Two manuscripts on platelet concentrates, one manuscript on antiresorptive drugs and one manuscript on the effects of biocorrosion, were presented for group analysis with subsequent discussion in the plenum and final consensus approval.Results and conclusions of the individual reviews of the three topics are presented in the respective papers. Conclusions of the group on strengths and weaknesses of available evidence as well as consensus statements and directions for further research are provided in this study. The following papers were subject to group discussions and formed the basis for the consensus statements: Stähli A, Strauss FJ, Gruber R. () The use of platelet-rich-plasma to enhance the outcomes of implant-related therapies: a systematic review Strauss FJ, Stähli A, Gruber R. (2018) The use of platelet-rich-fibrin to enhance the outcomes of implant-related therapies: a systematic review Mombelli A, Hashim D, Cionca N. () What is the impact of titanium particles and bio-corrosion on implant survival and complications? A critical review Stavropoulos A, Bertl K, Pietschmann P, Pandis N, Morten Schiødt, Klinge B. () The effect of antiresorptive drugs on implant therapy: a systematic review.

OBJECTIVES This prospective study analyzed the accuracy of implant placement with mucosa-supported stereolithographic guides, executed by inexperienced surgeons supervised by an experienced colleague. MATERIAL AND METHODS For the accuracy analysis, 75 OsseoSpeed implants™, placed in 17 fully edentulous jaws (16 patients) using a mucosa-supported stereolithographic guide (IMPLANT SAFE Guide, DENTSPLY Implants) and the Facilitate™ protocol, were included. DICOM images of the pre-surgical planning and the post-surgical CBCT were matched using the Mimics(®) software (Materialise Dental). These data were compared with the data (12 jaws, 52 implants) of an experienced surgeon (Vercruyssen et al. Journal of Clinical Periodontology 2014; doi:10.1111/jcpe.12231). RESULTS The global deviation at the coronal and apical point was 0.9 mm (SD 0.5) and 1.1 mm (SD 0.5), respectively. Depth deviations were 0.5 mm (SD 0.5) and 1.1 mm (SD 0.5), respectively, and the angular deviation was 2.8° (SD 1.5°). These deviations were statistically not inferior to the deviations of the experienced surgeon and also within the range of deviations reported by several systematic reviews. CONCLUSION Within the limitations of this study and for the above-mentioned surgical protocol, inexperience of the surgeon had no influence on the accuracy of implant placement in fully edentulous jaws, when all steps needed for the procedure are supervised by experienced dentists.

Aim To assess the accuracy of guided surgery compared with mental navigation or the use of a pilot-drill template in fully edentulous patients. Material and methods Sixty consecutive patients (72 jaws), requiring four to six implants (maxilla or mandible), were randomly assigned to one of the following treatment modalities: Materialise Universal® mucosa, Materialise Universal® bone, Facilitate™ mucosa, Facilitate™ bone, mental navigation, or a pilot-drill template. Accuracy was assessed by matching the planning CT with a postoperative CBCT. Deviations were registered in a vertical (depth) and horizontal (lateral) plane. The latter further subdivided into BL (bucco-lingual) and MD (mesio-distal) deviations. Results The overall mean vertical deviation for the guided surgery groups was 0.9 mm ± 0.8 (range: 0.0–3.7) and 0.9 mm ± 0.6 (range: 0.0–2.9) in a horizontal direction. For the non-guided groups, this was 1.7 mm ± 1.3 (range: 0.0–6.4) and 2.1 mm ± 1.4 (range 0.0–8.5), respectively (P

European Association of Osseointegration, EAO 22nd Annual Scientific Meeting, Dublin, Ireland 17-19 October 2013

OBJECTIVE: The predictability and simplicity of the Summers' technique for sinus floor elevation encouraged many clinicians to consider this new approach. The impact of such intervention on the sinus mucosa has, however, not been explored extensively. This pilot study followed the response of the Schneiderian membrane, longitudinally, via cone-beam CT images. MATERIAL AND METHODS: Ten consecutive patients (five women, mean age 58.7 years) referred for implant therapy in the posterior part of the maxilla, in combination with a trans-alveolar sinus floor elevation (13 sinuses involved), were enrolled. CBCT images were taken prior to and at 1 week and 1 month after surgery. The changes in thickness of the Schneiderian membrane were scored at nine standardized points per sinus using reformatted cross-sectional images. RESULTS: One week after sinus floor elevation, the Schneiderian membrane showed a significant swelling of 9.2 mm in the middle (SD 0.3; P

Aim To assess the accuracy of static computer-guided implant placement. Material and methods Electronic and manual literature searches were conducted to collect information on the accuracy of static computer-guided implant placement and meta-regression analyses were performed to summarize and analyse the overall accuracy. The latter included a search for correlations between factors such as: support (teeth/mucosa/bone), number of templates, use of fixation pins, jaw, template production, guiding system, guided implant placement. Results Nineteen accuracy studies met the inclusion criteria. Meta analysis revealed a mean error of 0.99 mm (ranging from 0 to 6.5 mm) at the entry point and of 1.24 mm (ranging from 0 to 6.9 mm) at the apex. The mean angular deviation was 3.81° (ranging from 0 to 24.9°). Significant differences for all deviation parameters was found for implant-guided placement compared to placement without guidance. Number of templates used was significant, influencing the apical and angular deviation in favour for the single template. Study design and jaw location had no significant effect. Less deviation was found when more fixation pins were used (significant for entry). Conclusion Computer-guided implant placement can be accurate, but significant deviations have to be taken into account. Randomized studies are needed to analyse the impact of individual parameters in order to allow optimization of this technique. Moreover, a clear overview on indications and benefits would help the clinicians to find the right candidates.

Objectives This study investigates the outcome of short implants additionally placed with longer implants to support a maxillary overdenture. Materials and methods Twelve patients received six implants to support a maxillary overdenture. Only one patient still had two molars in the maxilla, while the others had no remaining teeth. The status of the opposing arch was diverse. The distal implant in each quadrant was 6 mm in height (S) and the middle implants ranged between 10 and 14 mm (L). All implants were placed following a one-stage procedure and early loaded (6 weeks). Clinical and radiological parameters were assessed 6, 12 and 24 months after loading. Results One short implant failed 2 weeks after surgery, probably due to early mobilization by the provisional prosthesis. The mean bone loss on the rough part of the implant was 0.7 mm (S) vs. 1.3 mm (L) during the first year and 0.3 mm (S) vs. 0.2 mm (L) during the second year after loading. The mean implant stability quotient values were 67 (S) vs. 70 (L) at placement and 75 (S) vs. 78 (L) after 1 year. At the 2-year follow- up, all prostheses were still stable and comfortable. Conclusion An overdenture on six implants, of which two have a reduced length, might represent a successful treatment option. No significant difference could be found between both implant lengths at 2 years' follow-up. However, bone loss with short implants may increase the likelihood of failure.

Objective: The impact of the implant position on the restorative outcome could justify guided surgery even for the single implants particularly in the aesthetic zone and especially when a simplified concept is available. Material and methods: Based on a plaster model, on which the soft tissues were mimicked (according to the thickness measured on a Cone-Beam CT), a tooth-supported, surgical template was prepared. The latter guided all drills so that even flapless implant insertion became possible. All implants were placed by students of the master-after-master training program in Periodontology. Results: The prospective cohort included a total of 34 implants, all of AstraTech (Osteospeed®) type, which were successfully inserted in 29 patients, 16 flapless, 32 onestage. The marginal bone along the integrated implants remained stable over time, with 0.13 mm loss during the first year. The aesthetic parameters were reassuring. Conclusions: This simple model-based concept seems to be reliable for the guided placement of single implants and the pre-operative preparation of their restorations. To cite this article: Marcelis K, Vercruyssen M, Naert I, Teughels W, Quirynen M. Model-based guided implant insertion for solitary tooth replacement: a pilot study. Clin. Oral Impl. Res. 23, 2012; 999–1003 doi: 10.1111/j.1600-0501.2011.02242.x

Objectives: The present study aims to identify radiographic methods revealing data that are most representative for the true peri-implant bone as assessed by histology. Materials and methods: Eighty implants were placed in 10 minipigs. To assess matching between different image modalities, measurements conducted on intra-oral digital radiographs (IO), cone beam computer tomography (CBCT) and histological images were correlated using Spearman's correlation. Paired tests (Wilcoxon test) were used to determine changes in the bone parameters after 2 and 3 months of healing. Results: Significant correlations between bone defect depth on IO and histological slices (r=+0.7, P

Objective: The inherent deformation and two-dimensional nature of panoramic radiographs jeopardise their interpretation and quantitative measurements. This study aims to estimate the degree of underestimation of available mesio-distal bone in the premolar area (comparing panoramic radiographs with multi-slice/cone-beam computer tomography [CT]) to determine the prevalence, width, length and position of the bony canal [artery] in the lateral sinus wall and to explore the prevalence, width and length of another (newly detected) bony canal at the palatal aspect of the upper canine. Material and methods: The distance between the distal side of the canine/first premolar and the mesial side of the first molar or the anterior wall of the maxillary sinus was measured on panoramic radiographs and corresponding multi-slice/cone-beam CT images (65 patients). Measurements were made at apical, mid-radicular and crestal regions, parallel to the occlusal plane. The presence and dimensions of the two above-mentioned intra-osseous canals were verified on multi-slice CT scans (144 patients) using reformatted cross-sectional images and/or axial slices. Results: For all 65 patients, panoramic radiographs underscored the mesio-distal distance of available bone in the upper premolar region (mean 2.9 mm, range 0.1–7.5 mm). An intra-osseous canal in the lateral maxillary sinus wall was clearly visible in 49.5% of the cases (mean diameter 1.4 mm). In the canine region, a bony canal was obvious in 32.9% of the cases, with a mean diameter of 1.23 mm. For both canals, there was no correlation between diameter and patient's age. Conclusions: Based on the present data, cone-beam CT imaging can be recommended for visualising anatomical structures during planning of sinus augmentation procedures. To cite this article: Temmerman A, Hertele S, Teughels W, Dekeyser C, Jacobs R, Quirynen M. Are panoramic images reliable in planning sinus augmentation procedures? Clin. Oral Impl. Res. 22, 2011; 189 –194. doi: 10.1111/j.1600-0501.2010.02000.x

Objective: This retrospective analysis evaluated the long-term outcome of two implants supporting an overdenture in the mandible, as well as the significance of some confounding factors (smoking, implant length, bone quality). Material and methods: All mandibular overdenture cases (n=495) treated during the past 25 years in our centre (with ≥5 years loading of the implants) were included in this study. General information (medical history, implant data, report on surgery) was retrieved from the patient's file. A large number of patients (n=248) were willing to visit the clinic for an additional follow-up visit. For the others, information on implant survival was collected by phone (n=121), or contact was impossible (57 had died, three were hospitalized and 66 could not be reached). In the latter group, information was used, up to their last visit to the clinic. An implant was considered as surviving if it was still in function in the mouth, without clear adverse effects (pain, swelling, mobility). A failure was defined as early if it occurred within the window, insertion-final prosthesis placement; afterwards, it was considered as late. Results: Most of the inserted implants (Branemark type) were of the turned (machined) type (95.5%), the remainder was anodized (TiUnite). The anchoring system was either a bar (86.3%), ball attachments (11.7%) or magnets (1.6%), and only some patients changed from one to the other (0.4%). Kaplan–Meier analyses showed a survival rate of 95.5% after 20 years of loading. Factors that influenced the outcome included smoking (90% rate for smokers) and the surgical protocol (reduced survival rate for one-stage-placed implants). Implant length and bone quality had no impact. Conclusions: These results fully support the two-implant overdenture concept in the mandible even in the long run. To cite this article: Vercruyssen M, Marcelis K, Coucke W, Naert I, Quirynen M. Long-term, retrospective evaluation (implant and patient-centred outcome) of the two-implants-supported overdenture in the mandible. Part 1: survival rate. Clin. Oral Impl. Res. 21, 2010; 357–365. doi: 10.1111/j.1600-0501.2009.01849.x

Background Recently, guided surgery has been introduced and several papers verified its accuracy. Aim While those studies reported on the accuracy of the entire procedure, this experiment wanted to make clinicians aware of the amount of the deviation that can already occur during the drilling procedure alone, due to the tolerance of the drill in the drill key. Material and methods Drilling was executed in plexi-glass with a maximal inclination of the drills within the drill keys. Results A mean deviation in angulation of 4.7 degrees occurred with a mean horizontal deviation at the implant shoulder of 0.8 mm and 1.8 mm at the apex of 13 mm implant. The deviation was further dependent of the implant length, the distance of the sleeve above the bone and the respective guiding system. Discussion Increasing the height of the drill key will minimize the inaccuracy. Conclusions The results from this experiment showed the importance of keeping the drill parallel to the guide in a centric position.

Aims: To explore the relationship between primary implant stability and different parameters related to implant or bone properties. Materials and methods: Twenty-four patients received a total of 136 Straumann SLActive implants. Resonance frequency analysis (RFA) was performed at implant placement, and RFA and Periotest (PTV) were scored at loading. Bone density [Hounsfield (HU) scores] and coronal cortical thickness at osteotomy sites were measured from pre-operative computerized tomography scans. Results: Implant length, diameter or the presence of bony dehiscence did not have a significant effect on the mean RFA scores at implant insertion. Significant linear relations were found between RFA or PTV scores and HU values (P

Objectives: To evaluate the implant survival rate, periodontal and radiographic parameters of non-submerged screw implants with two different surfaces (TPS and SLA) in periodontally non-susceptible patients (NSP) and in patients with chronic adult periodontitis (CAP) or with generalized aggressive periodontitis (GAP). Material and methods: In 110 healthy partially edentulous subjects, 68 patients with CAP and 16 patients with GAP, a total of 513 implants were installed and followed for on average 48.1 +/- 25.9 months. Only fixed partial dentures were used as suprastructures. All patients were offered a supportive periodontal maintenance program. Smoking habits, health impairment, plaque score, bleeding on probing (BOP), type of surface, bone score, bone loss on radiographs and the number of failed implants were noted. Results: Implant survival in the NSP and CAP group was 98% and 96% after 140 months (NS), but only 80% after 100 months in the GAP group (P=0.0026). The overall rate of implant loss was 4.7%, but 15.25% in the GAP group (6/16 patients). The average marginal bone loss for all implants was 0.12 +/- 0.71 mm on the mesial side and 0.11 +/- 0.68 mm on the distal side. Bone loss/year was 0.08 +/- 0.31 and 0.07 +/- 0.3 mm in the NSP group, but 0.17 +/- 0.2 and 0.17 +/- 0.19 mm in the GAP group. Only in the GAP group, was bone loss significantly related to BOP, age, inflammation, presence of plaque, probing depth. Implants with a TPS surface had a lower survival than implants with an SLA surface (93% vs. 97%; P=0.06), especially in the GAP group (80% vs. 83%; P=0.005). Smoking habits had a significant influence on implant survival only in the GAP group (P=0.07), declining in current smokers to 63%, and to 78% in former smokers. Overall, impaired general health had no significant influence (P=0.85). However, impaired health further reduced implant survival in the GAP group (survival: 71%). In a statistical model to predict the chance for implant failing, only periodontal classification (P=0.012) and implant surface type (P=0.027) were significant. Conclusion: Periodontally healthy patients and patients with CAP show no difference in peri-implant variables and implant survival rate, but patients with GAP have more peri-implant pathology, more marginal bone loss and a lower implant survival implant rate. SLA surface had a better prognosis than the TPS surface.

Background: Since intra-bony pathologies might jeopardize implant outcome, their preoperative detection is crucial. Material and methods: In sixteen human cadaver bloc sections from upper and lower jaws, artificial defects with progressively increasing size (n=7) have been created. From each respective defect, analogue and digital intra-oral radiographs were taken, the latter processed via a periodontal filter and afterwards presented in black-white as well as in colour, resulting in three sets of 7 images per bloc section. Eight observers were asked to diagnosis an eventual defect on randomly presented radiographs, and at another occasion to rank each set based on the defect size. Results: The clinicians were only able to identify a defect, when the junctional area was involved, except for bony pieces with a very homogeneous structure. Conclusion: For longitudinal evaluation of healing bone (e.g. after tooth extraction), colour digital images can be recommended. These observations indicate that intra-oral radiographs are not always reliable for the detection of any intra-bony defect.

Introduction: Several surgical techniques and prosthetic devices have been developed in the last decades, aiming to improve aesthetic, hygienic and functional outcomes that may affect the peri-implant tissues, such as procedures of bone and soft tissue augmentation and the use of custom-made abutments of titanium and zirconium.Materials and methods: Three systematic reviews, based on randomized clinical trials and prospective studies covering the above reported topics were analysed, and the detected evidence was exposed to interactive experts' discussion during the group's and general assembly's meetings of the 4th EAO Consensus Conference. The results are reported using the following abbreviations: ST: short-term evidence, M-T: medium-term evidence; L-T: long-term evidence; LE: limited evidence.Results: Soft tissue augmentation procedures may be indicated for the increase of soft tissue thickness and keratinized tissue, the reduction of interproximal peri-implant bone loss, and the coverage of shallow peri-implant soft tissue recessions (S-T, LE), L-T is lacking. Guided bone regeneration approaches (GBR) showed efficacy when used for ridge reconstruction after the complete healing of the soft tissues (S-T & L-T), and the stability of the augmented bone may play a role in the maintenance of the soft tissue position and dimensions (LE). No significant differences were observed between titanium and zirconia abutments when evaluating probing pocket depth, bleeding on probing, marginal bone levels and mucosal recessions. Zirconia abutments were associated with more biological complications but demonstrated superiority in terms of achieving natural soft tissue colour (S-T).

To examine the existing evidence in identifying risk indicators in the etiology of peri-implantitis.A literature search was performed in MEDLINE via PubMed database of the US National Library of Medicine, for articles published until October 2014 using Medical Subject Heading search terms + free text terms and in different combinations.The microbiota associated with peri-implantitis is complex, demonstrating differences and similarities to the one seen at periodontitis sites. Plaque accumulation at dental implants triggers the inflammatory response leading to peri-implant mucositis/peri-implantitis. Individuals with a history of periodontal disease and smokers have an increased risk of developing peri-implantitis. There is some evidence to support the role of genetic polymorphism, diabetes, and excess cement as risk indicators for the development of peri-implantitis. There is also evidence to support that individuals on regular maintenance are less likely to develop peri-implantitis and that successful treatment of periodontitis prior to implant placement lowers the risk of peri-implantitis.Plaque accumulation at implants will result in the development of an inflammation at implants. A history of periodontal disease, smoking, excess cement, and lack of supportive therapy should be considered as risk indicators for the development of peri-implantitis.

Aim To give an overview of the workflow from examination to planning and execution, including possible errors and pitfalls, in order to justify the indications for guided surgery. Material and methods An electronic literature search of the PubMed database was performed with the intention of collecting relevant information on computer-supported implant planning and guided surgery. Results Currently, different computer-supported systems are available to optimize and facilitate implant surgery. The transfer of the implant planning (in a software program) to the operative field remains however the most difficult part. Guided implant surgery clearly reduces the inaccuracy, defined as the deviation between the planned and the final position of the implant in the mouth. It might be recommended for the following clinical indications: need for minimal invasive surgery, optimization of implant planning and positioning (i.e. aesthetic cases), and immediate restoration. Conclusions The digital technology rapidly evolves and new developments have resulted in further improvement of the accuracy. Future developments include the reduction of the number of steps needed from the preoperative examination of the patient to the actual execution of the guided surgery. The latter will become easier with the implementation of optical scans and 3D-printing.

AIM: To assess the accuracy and patient-centered outcome of a novel guided surgery system for placing implants in an edentulous maxilla. MATERIAL AND METHODS: Fifteen consecutive patients with sufficient bone to place six implants in the maxilla were randomly assigned to the immediate loading (with delivery of the final prosthesis within 24 h) or the delayed loading treatment group. Accuracy was assessed by matching the planning CT with a postoperative CBCT. Patient-centered outcome measures were the Dutch version of the McGill Pain Questionnaire (MPQ-DLV), the health-related quality of life instrument (HRQOL), visual analog scales (VAS), the duration of the procedure, and the analgesic doses taken each day. RESULTS: A mean deviation was found at the entry point of 0.9 mm (range: 0.1-4.5, median 0.8) and of 1.2 mm (range: 0.2-4.9, median 1.1) at the apex, and an angular deviation of 2.7° (range: 0.0-6.6°, median 2.3) was observed. The mean vertical deviation was 0.5 mm (range: 0.0-3.2, median 0.4), and in a horizontal direction, this was 0.7 mm (range: 0.1-3.1, median 0.6). The mean deviation in mesio-distal direction was 0.5 mm (range: 0.0-2.3, median 0.4) and in bucco-lingual direction 0.5 mm ± 0.4 (range: 0.0-2.2, median 0.3). No statistical differences could be shown between treatment groups on pain response (MPQ-DLV), treatment perception (VAS), number or kind of pain killers, or for the HRQOLI instrument. CONCLUSION: The accuracy of a novel CT-based guide is comparable to the accuracy data of other systems. Within the limitations of this study, no difference could be found in patient-centered outcome variables after immediate or delayed loading. ispartof: Clinical Oral Implants Research vol:27 issue:4 pages:427-432 ispartof: location:Denmark status: published

Background: From an ecological viewpoint, the oral cavity, in fact the oro-pharynx, is an 'open growth system'. It undergoes an uninterrupted introduction and removal of both microorganisms and nutrients. In order to survive within the oro-pharyngeal area, bacteria need to adhere either to the soft or hard tissues in order to resist shear forces. The fast turn-over of the oral lining epithelia (shedding 3 x/day) is an efficient defence mechanism as it prevents the accumulation of large masses of microorganisms. Teeth, dentures, or endosseous implants, however, providing non-shedding surfaces, allow the formation of thick biofilms. In general, the established biofilm maintains an equilibrium with the host. An uncontrolled accumulation and/or metabolism of bacteria on the hard surfaces forms, however, the primary cause of dental caries, gingivitis, periodontitis, peri-implantitis, and stomatitis. Objectives: This systematic review aimed to evaluate critically the impact of surface characteristics (free energy, roughness, chemistry) on the de novo biofilm formation, especially in the supragingival and to a lesser extent in the subgingival areas. Methods: An electronic Medline search (from 1966 until July 2005) was conducted applying the following search items: 'biofilm formation and dental/oral implants/surface characteristics', 'surface characteristics and implants', 'biofilm formation and oral', 'plaque/biofilm and roughness', 'plaque/biofilm and surface free energy', and 'plaque formation and implants'. Only clinical studies within the oro-pharyngeal area were included. Results: From a series of split-mouth studies, it could be concluded that both an increase in surface roughness above the R(a) threshold of 0.2 mum and/or of the surface-free energy facilitates biofilm formation on restorative materials. When both surface characteristics interact with each other, surface roughness was found to be predominant. The biofilm formation is also influenced by the type (chemical composition) of biomaterial or the type of coating. Direct comparisons in biofilm formation on different transmucosal implant surfaces are scars. Conclusions: Extrapolation of data from studies on different restorative materials seems to indicate that transmucosal implant surfaces with a higher surface roughness/surface free energy facilitate biofilm formation. To cite this article: Teughels W, Van Assche N, Sliepen I, Quirynen M. Effect of material characteristics and/or surface topography on biofilm development. Clin. Oral Imp. Res. 17 (Suppl. 2), 2006; 68-81. ispartof: Clinical oral implants research vol:17 issue:S2 pages:68-81 ispartof: location:SWITZERLAND, Pfaffikon status: published

Oral implants pierce through the mucosa thus establishing a connection between the oral environment and underlying tissues. The soft-tissue connection to the transmucosal part is of crucial importance as it relates to the stability of the peri-implant tissues and the prevention of peri-implant infection with subsequent destruction of the peri-implant structures. The adhesion of soft tissue to the material surface is one prerequisite for the longterm success. This adhesion is depending upon the topography and chemical composition of the implanted biomaterial. As regards to surface topography of implants we refer to the definitions proposed by Albrektsson & Wennerberg (2004a, 2004b), where minimally rough surface has been defined in the range of Sa 0.5–1 mm (e.g., turned implants), moderately rough Sa 1–2 mm (e.g., acid etched, sandblasted or anodized) and rough Sa 42mm (e.g., plasma sprayed).

Background: Periodontitis and peri-implantitis are linked to the presence of several key pathogens. The treatment of these infectious processes therefore involves the reduction/eradication of bacteria associated with periodontitis. Methods: This prospective, split-mouth, single-blind study followed the colonization of ‘pristine’ sulci created in 42 partially edentulous patients during implant surgery (e.g. abutment connection). The hypothesis was that the composition of the maturing subgingival plaque in these ‘fresh’ peri-implant pockets would soon (within 2 weeks) be comparable to the subgingival microbiota of teeth with similar clinical parameters (reference sites), including the presence of bacteria associated with periodontitis. Per patient, four subgingival plaque samples were taken from shallow and medium pockets around implants (test sites), and teeth within the same quadrant (undisturbed microbiota as control sites), 1, 2, 4, 13, 26 and 78 weeks after abutment connection, respectively. The samples were analysed by either checkerboard DNA–DNA hybridization, or cultural techniques, or real-time polymerase chain reaction (PCR) for intra-subject comparisons (teeth vs. implant, for comparable probing depths). Results: Checkerboard DNA–DNA hybridization and real-time PCR revealed a complex microbiota (including several pathogenic species) in the peri-implant pockets within 2 weeks after abutment connection. After 7 days, the detection frequency for most species (including the bacteria associated with periodontitis) was already nearly identical in samples from the fresh peri-implant pockets (5% and 20% of the microbiota belonging to red and orange complex, respectively) when compared with samples from the reference teeth. Afterwards (e.g. between weeks 2 and 13), the number of bacteria in peri-implant pockets only slightly increased (±0.1 log value), with minor changes in the relative proportions of bacteria associated with periodontitis (8% and 33% of the microbiota belonging to red and orange complex, respectively). Although small differences were seen between teeth and implants at week 2 with cultural techniques, a striking similarity in subgingival microbiota was found with this technique from month 3 on, with nearly identical detection frequencies for bacteria associated with periodontitis for both abutment types. Conclusions: This study indicates that the initial colonization of peri-implant pockets with bacteria associated with periodontitis occurs within 2 weeks.

Background: Recent case reports introduced the term retrograde peri-implantitis as a lesion (radiolucency) around the most apical part of an osseointegrated implant. It develops within the first months after insertion. This retrospective study aimed to find predisposing conditions for such peri-apical lesions and to evaluate treatment strategies. Methods: All single implants (426 in the upper, 113 in the lower jaw, all Branemark system® type) placed at the department of Periodontology of the University Hospital (Catholic University Leuven) were included in this retrospective evaluation to check the incidence of retrograde peri-implantitis. Eventual predisposing factors such as patient characteristics (age, medical history), recipient site (local bone quality and quantity, cause of tooth loss), periodontal and endodontic conditions of neighboring teeth, implant characteristics (length, surface characteristics), and surgical aspects (guided bone regeneration, osseous fenestration, or dehiscency) were considered. Moreover, implants with retrograde peri-implantitis were followed longitudinally to verify their treatment outcome by means of different parameters (Periotest® values (PTV), marginal bone level, radiological size of peri-apical defect). Results: Seven implants in the upper (1.6%) and 3 in the lower jaw (2.7%) showed retrograde peri-implantitis, before or at abutment connection. In comparison with successful implants, such peri-apical lesions occurred preferably at sites with a history of an obvious endodontic pathology of the extracted tooth to be replaced. The incidence of retrograde peri-implantitis was significantly higher (P

Although a two-stage procedure with symphyseal oral implants can lead to a long-term (15 years) 99% cumulative survival rate, a one-stage approach with immediate loading via prefabricated elements seems to offer a short-term acceptable outcome with significantly lower costs. A series of 50 consecutive patients, not eliminated for any systemic or smoking condition, received at the department of periodontology three implants in the symphyseal area, connected by a very rigid horse shoe-shaped titanium bar. A final screw retained prosthetic framework was placed on top of it at the department of prosthetic dentistry within 2 days after surgery (44) or after a delay, due to purely external factors, of up to 10 days (6). Forty-five patients were followed for 1 year. In one patient, all three implants failed and another four patients were lost to follow-up. The cumulative failure rates for implants and prostheses at 1 year were, respectively, 7.3% and 5%. The mean marginal bone loss at 1 year was 1.08 mm (SD: 1.62; range −5.68 to +2.55). This study shows that stable marginal bone levels can be maintained around immediately loaded implants in the lower jaw in an average patient population for at least 1 year. The survival rate is, however, lower than for a staged approach.

This study aimed to analyse variations in the mandibular interforaminal morphology in an attempt to identify potential risks or contraindications for surgery, especially implant installation, in this particular region. A total of 210 spiral computer tomography (CT) examinations of patients requiring endosseous implant installation in the lower jaw were re-evaluated to explore anatomical variations in bone morphology (shape and contour), and to measure parameters concerning height, width and inclination of the bone in the symphyseal atrea. All measurements were performed on the cross-sectional reformatted images mesial to the mental foramina. A lingual concavity (with a depth of 6 +/- 2.6 mm) was observed in 2.4% of the jaws, with a remaining bone height in that area ranging from 4.2 to 11.9 mm. A clearly lingual tilted/inclined morphology was seen in 28.1% of jaws with a mean angle of 67.6 +/- 6.5 degrees, but a relatively constant width (> 8.8 mm). The remaining jaws (69.5%) showed a slight broadening in the caudal direction. The morphologic parameters were influenced neither by age nor by gender. In conclusion, mandibles with a lingual concavity or a severe slope of the lingual cortex might confer increased risks of lingual perforations during trepanation surgery or graft harvesting as well as fenestrations during implant installation. The detection frequency of such variations within the lower jaw seems to advocate a profound dissection of the lingual site and, in the case of some special treatment strategies, additional cross-sectional radiography.

It has already been shown that occlusive titanium barriers have osteoconductive properties. These barriers, however, cover only a limited surface area and have only been used in animal experiments. The aim of this study was to evaluate bone neogenesis under a pre-shaped titanium barrier placed over the top of the rabbit skull and the top of highly resorbed edentulous upper-jaw bone in patients. Computed tomography (CT) scans made it possible to pre-shape the titanium barrier according to individual bone shape in human experiments. On the rabbit skull, tissue augmentation of up to 6 mm 1 year after barrier placement was observed, while the original thickness of skull bone was on average between 1.5 and 2.5 mm. The bone, which remained histologically immature for 1 year, grew systematically along the titanium surface, illustrating its osteoconductivity. Even after removal of the barrier, on average, 75.3 and 59.4% of the newly created tissue volume was maintained after 3 and 9 months, respectively. Clinical observations on 10 consecutive patients showed that, in those (5/10) in which the barrier remained unexposed for several months, an increase of the jawbone height and width of up to 16 mm could be observed when the barrier was removed after 12-18 months. As in the rabbits at barrier removal, the bone demonstrated a limited degree of mineralization as ascertained from biopsies. This newly formed osteoid tissue allowed the insertion of 33 screw-shaped titanium implants which in most cases (30/33) successfully osseointegrated to support a fixed prosthesis. The surrounding marginal bone level remained stable even up to 5 years after implant placement. Both animal and clinical data demonstrate that guided bone neogenesis under a subperiosteally placed titanium barrier can reach large volumes.

The aim of the present study was to assess the influence of endogenous and local factors on the occurrence of implant failure up to the abutment stage. The study comprised a group of 399 consecutive patients, which represented the total of patients who had been treated from 1995 to 1997 (with a total of 1263 Branemark Bran-system implants) at the Department of Periodontology of the University Hospital, Catholic University Leuven. For each patient, the medical history was carefully examined. Data collection and analysis were mainly focused on endogenous factors such as hypertension, osteoporosis, hypo- or hyperthyroid function, chemotherapy, diabetes type I or II, Crohn's disease, some local factors (e.g. bone quality, reason for tooth loss) and breach of sterility during surgery. The reason for tooth loss, smoking habits, radiotherapy and other local bone factors (bone quality and quantity) were also recorded. Implant failures were recorded up to the abutment connection. The present study indicated a success rate until this stage of 97.8%. General factors such as heavy smoking, chemotherapy plus poor bone quality increased implant failure rate. Radiotherapy, limited bone volume and claustrophobia, which led to breaching the strict preoperative rules of asepsis, appeared to be the most relevant local factors for early implant failures.

The purpose of this study was to evaluate over time the marginal bone level changes around implants installed to treat partial edentulism and to investigate the possible effect of several confounding variables. Consecutive intraoral radiographs taken with the paralleling technique were used. In all, 660 partially edentulous patients ever treated in the departments (248 males; 15-83 years of age) with 1655 implants, which were successfully integrated at abutment connection, were loaded by means of fixed partial prostheses. The observation period starting at abutment connection reached 16 years (mean 5.1). Implants were divided into three groups: 235 implants supported single-tooth crowns, 398 supported implant-tooth connected and 1022 free-standing fixed partial prostheses. Implants were placed in maxilla and mandible, both anteriorly and posteriorly. No significant difference in bone level evolution was predicted between the three groups of implants, either for posterior or for anterior sites. The estimated marginal bone loss for the first 6 months is 0.31 mm/year and after that 0.015 mm/year higher in the maxilla than in the mandible. More bone loss was predicted for the first 6 months when dehiscences existed, when a membrane or a bone graft were used, or when metal/ceramic prosthesis material was applied. Age and gender did not affect the change in bone level. The use of subsequently situated single-implant crowns to restore an edentulous space did not lead to more marginal bone loss than around splinted implants. Based on marginal bone height maintenance, the excellent prognosis of the presently used implants to support restorations in the treatment of partial edentulism was confirmed.

The purpose of this study was to predict the outcome of implant restorations in the treatment of partial edentulism, taking into account implant interdependency and the effect of several confounding variables. Between December 1982 and June 1998, 1956 Branemark system implants (1212 and 744 in the maxilla and mandible, respectively, 846 distal to first premolars) were installed in 660 patients (248 males) at the Department of Periodontology of the University Hospitals of the Catholic University of Leuven. Of the 810 restorations installed at the Department of Prosthetic Dentistry of the same hospital, 235 were single crowns, 166 were supported by implants and teeth and 409 were free-standing fixed partial prostheses. An additional 87 restorations was placed in private dental offices and were not included. The patients were followed from implant installation until June 1999. The estimated cumulative survival rates were 91.4% for all implants and 95.8% for all restorations over a period of 16 years. Estimated cumulative survival rates from loading for implant-tooth connected and free-standing implants were, respectively, 93.6% and 97.2%. Neither jaw site nor implant position (anterior-posterior) had any significant effect on the outcome. Short implant length, high number of implants per patient, low number of implants per prosthesis, implants loaded by acrylic-veneered restorations and implants combined with bone grafting present a higher risk hazard for implant failure. The idea of not splinting the implants in a fixed partial prosthesis is promising but needs replication before accepting it.

The use of oral implants in the rehabilitation of partially and fully edentulous patients is widely accepted even though failures do occur. The chance for implants to integrate can for example be jeopardised by the intra-oral presence of bacteria and concomitant inflammatory reactions. The longevity of osseointegrated implants can be compromised by occlusal overload and/or plaque-induced peri-implantitis, depending on the implant geometry and surface characteristics. Animal studies, cross-sectional and longitudinal observations in man, as well as association studies indicate that peri-implantitis is characterised by a microbiota comparable to that of periodontitis (high proportion of anaerobic Gram-negative rods, motile organisms and spirochetes), but this does not necessarily prove a causal relationship. However, in order to prevent such a bacterial shift, the following measures can be considered: periodontal health in the remaining dentition (to prevent bacterial translocation), the avoidance of deepened peri-implant pockets, and the use of a relatively smooth abutment and implant surface. Finally, periodontitis enhancing factors such as smoking and poor oral hygiene also increase the risk for peri-implantitis. Whether the susceptibility for periodontitis is related to that for peri-implantitis may vary according to the implant type and especially its surface topography.

The relationship between periodontitis and peri-implantitis remains a matter of debate. The present study compared, "within" randomly chosen partially edentulous patients (n=84 subjects, 97 jaws), the marginal bone loss around teeth and implants during 5 years (range 3 to 11 years) following the first year of bone remodelling. The patients had all been rehabilitated by means of screw-shape c.p. titanium implants with a machined surface (Branemark system). During the 5 years observation interval, periodontal parameters (marginal bone and attachment loss, the latter for teeth only) were collected together with data on confounding factors (smoking, oral hygiene, tooth loss). Marginal bone loss was measured through long-cone intra-oral radiographs. The mean "interval" bone loss was significantly (P=0.0001) higher around teeth (0.48+/-0.95 mm) than around implants (0.09+/-0.28 mm). The corresponding data for the "worst" performing tooth (0.99+/-1.25 mm) and implant (0.19+/-0.32 mm) per subject showed the same tendency. Neither attachment nor bone loss around teeth correlated with marginal bone loss around implants. This study indicated that the rate of bone loss around screw-shape c.p. titanium implants with a machined surface (Branemark system implants) was not influenced by the progression rate of periodontal destruction around the remaining teeth within the same jaw.

For several radiological examinations, a clinician can select between conventional and spiral computed tomography. Using both techniques, this study aimed at evaluating the difference in absorbed doses when examining a single lateral jaw segment in a human cadaver head and Rando phantom. The present study involved the placement of thermoluminescent dosimeter (TLD) chips (GR-200) in the thyroid gland, and bilaterally, in the parotid and submandibular glands and the lenses of the eyes in both a human cadaver and a Rando phantom at corresponding locations. Consecutive conventional spiral tomographic examinations were carried out in both the left upper and lower premolar area, using a Cranex TOME multifunctional unit. Each examination consisted of 4 slices with a 2 mm slice thickness and exposure parameters of 57 kV, 56 seconds and 1.6-2.0 mA. Regarding spiral computed tomography (CT), a Somatom Plus S scanner (Siemens, Erlangen, Germany), with a slice thickness of 1 mm with settings at 120 kV and 165 mA, was used on both phantoms and separately in the upper and lower jaw. With conventional tomography, the findings of the present study showed that the parotid and submandibular glands on the side near the X-ray tube received the highest dose, both for the cadaver head (doses ranging from 0.5 to 1.3 mGy) and the phantom (doses ranging from 0.6 to 2.6 mGy). For CT of the upper jaw, the highest doses were delivered to the parotid glands with an average absorbed dose of 9.2 and 10.6 mGy for the cadaver head and phantom, respectively. The submandibular glands received the highest doses during CT examination of the lower jaw with an average of 7.8 and 12.9 mGy for the cadaver head and phantom, respectively. It appears from the present investigation that if small edentulous regions are examined, radiation doses during conventional tomography remain much lower than during CT imaging. However, when multiple tomographic cuts are required, a spiral CT examination can replace a series of conventional examinations, especially in cases such as the rehabilitation of an edentulous upper jaw or a more complex surgery.

For certain surgical procedures (e.g. placement of implants), an accurate localisation of the mandibular canal is of utmost importance to avoid injuries to the neurovascular bundle. The aim of the present study was to evaluate, on human fresh cadavers (n=6), the accuracy of conventional spiral tomography for the localisation of the mandibular canal. By means of the Cranex TOME® multifunctional unit (Orion Corporation Soredex, Helsinki, Finland), tomographic slices were taken at 3 different locations in the left posterior mandible (distal to the mental foramen). The mandibles were then sectioned at these 3 sites with a microtome. With a digital sliding calliper, the following 3 measurements were performed both on the tomograms and the bone sections at the three sites: 1) distance from the crest to mandibular canal, 2) overall bone height and 3) bone width. Overestimations of the distance to the mandibular canal (8/18) ranged from 1.05 to 0.10 mm and underestimations from 0.30 to 1.36 mm. The same number of over- and underestimations occurred for the bone height (1.14 to 0.14 mm and 0.15 to 1.40 mm, respectively). The bone width scored more overestimations (10/18), ranging from 1.40 to 0.12 mm, while underestimations ranged from 0.25 to 1.35 mm. From the present results, it is concluded that spiral tomography using the Cranex TOME® multifunctional X-ray unit provides accurate information and sufficient detail for preoperative planning of implant placement in the posterior mandible.

The head of a human cadaver was positioned in a Cranex TOME® multifunctional unit (Orion Corporation Soredex, Helsinki, Finland) to measure the organ radiation doses after tomographic examinations of the upper and lower edentulous jaw bone. Five consecutive examinations were carried out in the upper and lower anterior jaw regions to cover the entire frontal area, 2 in the upper and lower left premolar regions, and 3 and 4 in the upper and lower left molar regions, respectively. Each examination consisted of 4 slices with a 2 mm slice thickness. Thermoluminescent dosimeter chips were placed in the thyroid gland and bilaterally in the parotid and submandibular glands. Dosimetric measurements were repeated for the different tomographic examinations mentioned above. For spiral tomography in the maxilla, organ doses for both parotid glands were most elevated, while those for the thyroid glands were the lowest. Average doses per examination reached levels of 0.27 mGy for the right (OS) parotid gland with frontal tomography, and 3.89 mGy and 1.67 mGy for the parotid gland at tube-side (TS) for premolar and molar tomography. For the thyroid gland, a minimal dose of ≤0.004 mGy was noticed for all examinations. For spiral tomography of the frontal area in the mandible, the OS parotid gland received the highest dose (0.77 mGy), while for an analysis of the premolar and molar areas, doses were more elevated for the TS parotid gland (1.22 mGy and 1.72 mGy, respectively). For the TS submandibular gland, organ doses were also raised, with values of 0.39 mGy for frontal, 1.31 mGy for premolar and 1.61 mGy for molar tomography. This study thus indicates that for conventional spiral tomographic examinations in the maxilla and the mandible, radiation doses for the TS submandibular and parotid glands were significantly more elevated than those to the thyroid gland. These values remain however below the organ doses previously reported for spiral CT involving both a full upper or lower jaw.

Clinical data indicate different medium and long-term outcomes of endosseous implants for different implant configurations and in particular implant surfaces. The present study compares 2 very similar implant systems but with different surface characteristics in a split-mouth-randomized design. The Astra-Tech (A) system (Astra-Tech AB, Molndal, Sweden) consisted of selftapping TiO2-blasted screw-shaped implants made of commercially pure titanium, and the Branemark (B) System (Nobel Biocare, Gothenburg, Sweden) comprised selftapping Mark II implants with machined surface irregularities. Throughout the 2-years' observation period, no significant differences could be found concerning probing depths, presence of plaque or change in marginal bone level. A statistically significant difference in location of the marginal bone level in relation to the shoulder of the implant was found in favor of the A system both at baseline and after 2 years. Cumulative success rates of 100% (A) and 97.7% (B) were not statistically different. From a prosthetic point of view, more soldering points were needed for A compared to B to reach clinical acceptable fit. More years of observation are needed to compare the fate of the soft and hard tissues surrounding two different implant surfaces.

Besides an a traumatic procedure. aseptic techniques during surgery have been suggested to have a positive impact on the predictability of osseointegration. To avoid an infection of the surgical field, coverage of the face of the patient (drapes) and nose (surgical mask. drape and plastic film) were advocated in order to reduce airborne infections and to prevent a contact contamination of instruments and gloves. Such a coverage, however. increases the feeling of claustrophobia when local anaesthesia is used and can lead to hypoxemia. The aim of the present study was to investigate whether the expired air via the nostrils could contribute to the contamination of the oral surgical field. Test blood agar plates were installed for 30 min under the nose of volunteers lying on a surgical table; once with full coverage of their nostrils, as indicated above, and once without. Simultaneously, control plates were installed on a table besides the patient to measure the basic contamination from the environment. All plates were incubated both aerobically and anaerobically. The number of colony forming units (c.f.u.) recorded on test plates after aerobic and anaerobic incubation were surprisingly low. with a mean score of 2.7 and 5.0 c.f.u. for the uncovered situation, and 2.5 and 3.3 c.f.u. for the covered situation, respectively. The control plates were infected by a nearly comparable number of bacteria (means ranging from 2.2 to 3.2). These findings indicate that covering nostrils by a mask and sterile adhesive plastic film IS not essential in avoiding airborne microbial contamination. However, the use of a meshed nose guard to prevent contact with the highly contaminated nasal skin is highly recommended.

OBJECTIVES: Narrow-diameter implants (NDIs) are used in severely resorbed mandibles. The reduced implant diameter means a reduction in the total contact surface between the implant and bone. The question arises whether the implant can be sufficiently osseointegrated to withstand loading forces. If not, marginal bone loss can result from overload. The aim of this retrospective study was to compare clinical and radiographic measurements and patient satisfaction of NDIs with those of regular-diameter implants (RDIs) placed in edentulous patients to support an overdenture via either a ball or a locator connection. MATERIAL AND METHODS: Retrospectively over a 7-year period, a total 119 patients fulfilled the inclusion criteria and were selected for this study. The patients received two 3.3- or 4.1-mm-diameter standard titanium implants in the mandible to support an overdenture. At maintenance examinations after 1 and 3 years, clinical peri-implant and prosthetic conditions, marginal bone (MB) and patient satisfaction were investigated. RESULTS: None of the 238 implants were lost during the 3-year follow-up period. Overall MB loss was statistically higher in the NDI group when compared with the RDI group. At the site level, a greater MB loss was observed at the distal side of both implant types. Implants with a locator showed significantly greater MB loss (0.38 mm) compared with the implants with a ball attachment (0.14 mm) over the two-year evaluation period (P = 0.006). Patient satisfaction significantly favoured the NDI (8.3) and the locator attachment (8.6). CONCLUSIONS: The results suggest that during the first three years after implantation, NDIs were associated with more marginal bone loss compared with RDIs. Regardless of implant diameter, the locator attachment showed more marginal bone loss over time compared with the ball attachment. ispartof: Clinical Oral Implants Research vol:26 issue:2 pages:149-156 ispartof: location:Denmark status: published

The hypothesis that teeth act as reservoirs of micro-organisms for the colonization of oral implants has recently been stated several times. The present study aimed at examining, in partially edentulous patients with severe periodontitis, whether pockets around teeth and implants harbored a comparable micro-flora. In 6 patients (3 with refractory periodontitis and 3 with advanced chronic adult periodontitis), plaque samples were taken from a deep and shallow pocket around both teeth and implants for differential phase contrast microscopy and DNA probe analysis. The results showed important differences in the sub-gingival flora between the 2 disease groups, as well as between deep and shallow pockets, around both implants and teeth. On the other hand, when pockets around teeth and implants with equal depths were compared a striking similarity was observed in the microbial composition. These observations confirm the hypothesis that pockets around teeth act as a reservoir and highlight the importance of periodontal health when oral implants are planned.