1. The value of macrophage inhibitory cytokine-1 level in differentiating benign from malignant solitary pulmonary nodules.
- Author
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Xu CH, Xue JS, Zhang XW, Yu LK, and Lin Y
- Subjects
- Biomarkers blood, Diagnosis, Differential, Enzyme-Linked Immunosorbent Assay, Female, Humans, Image-Guided Biopsy, Lung Diseases blood, Lung Neoplasms blood, Male, Middle Aged, ROC Curve, Retrospective Studies, Solitary Pulmonary Nodule blood, Tomography, X-Ray Computed, Growth Differentiation Factor 15 administration & dosage, Lung Diseases diagnosis, Lung Neoplasms diagnosis, Solitary Pulmonary Nodule diagnosis
- Abstract
Introduction: Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-β superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers., Objectives: The aim of this study was to explore the diagnostic value of serum MIC-1 in patients with solitary pulmonary nodules (SPNs)., Methods: Serum specimens from 158 malignant SPN patients, 110 benign SPN patients, along with 120 healthy volunteers. The levels of serum MIC-1 were measured by sandwich enzyme-linked immunosorbent assay., Results: Serum levels of MIC-1 in malignant SPN patients were significantly higher than those in benign SPN patients (P < .01), or those in healthy volunteers (P < .01). With a cutoff of 685.8 pg/ml, the sensitivity and specificity of MIC-1 in differentiating between malignant SPN patients and benign SPN patients, and between malignant SPN patients and healthy volunteers was, 56.3% and 92.7%, and 65.8% and 96.7%, respectively. An area under the curve (AUC) for malignant SPN resulting from MIC-1, which was significantly better than any other tumor markers tested including carbohydrate antigens 12-5 (CA125), and carcinoembryonic antigen (CEA)., Conclusions: In conclusion, measurement of serum MIC-1 levels could be considered as a diagnostic biomarker for malignant SPN patients., (© 2017 John Wiley & Sons Ltd.)
- Published
- 2018
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