1. PTX3, Anti-PTX3, and Anti-C1q Autoantibodies in Lupus Glomerulonephritis
- Author
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Silvano Bettio, Alberto Mantovani, Anna Ghirardello, Leonardo Punzi, Monica Ceol, Dorella Del Prete, Luca Iaccarino, Margherita Zen, Nicola Bassi, Mariele Gatto, and Andrea Doria
- Subjects
Adult ,Male ,medicine.medical_specialty ,Allergy ,Adolescent ,urologic and male genital diseases ,Kidney ,Gastroenterology ,Autoantigens ,Young Adult ,immune system diseases ,Fibrosis ,Internal medicine ,Renal fibrosis ,Immunology and Allergy ,Medicine ,Humans ,skin and connective tissue diseases ,Acute-Phase Reaction ,Autoantibodies ,Proteinuria ,biology ,business.industry ,Complement C1q ,General Medicine ,PTX3 ,DNA ,Middle Aged ,medicine.disease ,Lupus Nephritis ,Staining ,Serum Amyloid P-Component ,Endocrinology ,C-Reactive Protein ,biology.protein ,Female ,medicine.symptom ,Antibody ,business ,Immunostaining ,Biomarkers - Abstract
Pentraxin 3 (PTX3) is an acute-phase protein involved in C1q clearance. The presence of anti-C1q and the absence of anti-PTX3 antibodies were associated with lupus glomerulonephritis (LGLN). Our aim was to assess soluble and kidney-expressed PTX3 and their relationships with anti-C1q and anti-PTX3 antibodies in LGLN. Serum PTX3, anti-C1q, anti-dsDNA, and anti-PTX3 antibodies were tested in 130 systemic lupus erythematosus (SLE) patients, 130 healthy and 127 disease controls. Twenty-nine renal biopsies from SLE patients were analyzed and PTX3 immunostaining was quantified by morphometric analysis. Parametric and nonparametric statistics were performed. PTX3 serum levels were lower in SLE versus controls, but they were correlated with proteinuria in LGLN patients (p = 0.001). LGLN patients had higher anti-C1q and lower anti-PTX3 antibody levels than those without (p
- Published
- 2015