1. Ethnicity and disease severity in ankylosing spondylitis a cross-sectional analysis of three ethnic groups
- Author
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Jamalyaria, Farokh, Ward, Michael M, Assassi, Shervin, Learch, Thomas J, Lee, MinJae, Gensler, Lianne S, Brown, Matthew A, Diekman, Laura, Tahanan, Amirali, Rahbar, Mohammad H, Weisman, Michael H, and Reveille, John D
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Autoimmune Disease ,Arthritis ,Adult ,Black or African American ,Black People ,Blood Sedimentation ,Cross-Sectional Studies ,Disease Progression ,Female ,HLA-B27 Antigen ,Hispanic or Latino ,Humans ,Longitudinal Studies ,Male ,Middle Aged ,Prospective Studies ,Reproducibility of Results ,Severity of Illness Index ,Spine ,Spondylitis ,Ankylosing ,White People ,Young Adult ,Ankylosing spondylitis ,Blacks ,Disease severity ,HLA-B27 ,Latinos ,Arthritis & Rheumatology ,Clinical sciences ,Immunology ,Allied health and rehabilitation science - Abstract
The purpose of this study is to compare disease severity in ankylosing spondylitis (AS) in three ethnic groups. We assessed 925 AS patients (57 Blacks, 805 Whites, 63 Latinos) enrolled in the longitudinal Prospective Study of Outcomes in AS (PSOAS) for functional impairment, disease activity, and radiographic severity. Comparisons of clinical characteristics and HLA-B27 frequency for each group were performed, in two multivariable regression models, we compared the baseline Bath Ankylosing Spondylitis Radiographic Index (BASRI) and modified Stokes Ankylosing Spondylitis Spine Score (mSASSS) by ethnicity, adjusting for covariates. Blacks had greater functional impairment (Bath Ankylosing Spondylitis Functional Index) (median 62.5 vs. 27.8 in Whites and 38.1 in Latinos; p
- Published
- 2017