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Your search keyword '"Frier, B. M."' showing total 12 results
Start Over Author "Frier, B. M." Journal clinical science
12 results on '"Frier, B. M."'

4. Reduced number of angiotensin II receptors on platelets in insulin-dependent diabetes

Author

Connell, J. M. C., Ding, Yu-An, Fisher, B. M., Frier, B. M., and Semple, P. F.

Abstract

1. Angiotensin II receptors on platelets were studied in 13 patients with uncomplicated type I diabetes mellitus and in 15 age-matched normal subjects. 2. Receptor density on cells from the diabetic patients was 15% lower than the normal subjects (5.2 ± 0.8 sd sites/platelet in diabetic patients and 6.4 ± 0.8 in normals, P < 0.001), but there were no differences in receptor affinity as measured by Kd (4.9 ± 1.5 × 10−10 mol/l in diabetic patients and 5.4 ± 1.4 × 10−10 mol/l in normals). 3. Plasma concentrations of renin and angiotensin II were similar in both groups. 4. The reduced density of angiotensin II receptors on platelets from patients with insulin-dependent diabetes may reflect a generalized abnormality of angiotensin II receptor regulation.

Published
1986
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5. Cholinergic Manifestations of the Acute Autonomic Reaction to Hypoglycaemia in Man

Author

Corrall, R. J. M., Frier, B. M., Davidson, N. McD., Hopkins, W. M., and French, E. B.

Abstract

1. The effects of insulin-induced hypoglycaemia on pupil size, parotid salivary secretion and sweating were studied in seven normal volunteers. 2. Hypoglycaemia was associated with an acute stimulation of parotid salivary secretion and of sweating, synchronous in onset with the rise in heart rate. There was no clear evidence of concurrent pupillary constriction.

Published
1983
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