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1. A double-blind comparison of a new ibuprofen-codeine phosphate combination, codeine phosphate, and placebo in the relief of postepisiotomy pain.

Author

Norman SL, Jeavons BI, O'Brien PM, Johnson IR, Hitchcock A, Noyelle RM, and Pickvance NJ

Subjects
Clinical Trials as Topic, Codeine administration & dosage, Codeine adverse effects, Double-Blind Method, Episiotomy, Female, Humans, Pregnancy, Random Allocation, Codeine therapeutic use, Pain, Postoperative drug therapy
Abstract

In a double-blind single-dose study, the analgesic effect of a new ibuprofen-codeine phosphate combination was compared with those of codeine phosphate alone and placebo for the relief of moderate and severe postepisiotomy pain. In the 113 patients studied, combination therapy was superior to codeine phosphate alone and to placebo, the difference between the combination and codeine phosphate alone reaching statistical significance (P less than 0.05) after two hours. The few side effects reported were not of a serious nature.

Published
1985

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