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Lung transplant recipients are at an increased risk for Clostridioides difficile infection (CDI), and those who develop CDI post‐transplant can have worsened outcomes including graft failure and death. We sought to describe the efficacy and safety of primary CDI prophylaxis with oral vancomycin among 86 adult lung transplant recipients. Overall, we observed a 9.3% (8/86) incidence of CDI among patients receiving prophylaxis, with the majority of infections occurring a median of 25 days after completion of prophylaxis. Furthermore, we observed a 4.7% incidence of VRE infection/colonization. Opportunities exist to optimize the duration of CDI prophylaxis to balance the benefits and risks in lung transplant recipients. [ABSTRACT FROM AUTHOR]

Background: Vaccine preventable diseases can affect solid organ transplant recipients post‐transplant. Therefore, the administration of vaccines and assessment of serologic response should be prioritized in the pre‐transplant period. Methods: This single‐center, retrospective study included 349 adult heart or lung transplant candidates between December 1, 2017 and November 30, 2019. We describe vaccination or serologic status for hepatitis A, hepatitis B, tetanus, pneumococcal, influenza, and other recommended vaccinations among heart or lung transplant candidates. Results: Eighty‐two heart transplant candidates (91%) and 77 lung transplant candidates (30%) received an ID consult prior to transplant. More patients completed the pneumococcal series (66.7% vs. 28.6%, P =.045) in the heart transplant group that received an ID consult. In the lung transplant group, patients with an ID consult demonstrated higher rates of immunity to hepatitis A (84.4% vs. 72.9%, P =.047), hepatitis B (75.3% vs. 56.9%, P =.005), and measles (71.4% vs. 52.5%, P =.005) compared to those without. Conclusions: Our results demonstrate the value of consulting ID and administering vaccinations in the early evaluation phase, prior to transplant listing. Opportunities remain to better optimize vaccination rates prior to transplant in heart and lung transplant candidates. [ABSTRACT FROM AUTHOR]