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1. Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats

Author

Luiz Henrique Marchesi Bozi, Izabel Regina dos Santos Costa Maldonado, Marcelo Perim Baldo, Márcia Ferreira da Silva, José Bianco Nascimento Moreira, Rômulo Dias Novaes, Regiane Maria Soares Ramos, José Geraldo Mill, Patricia Chakur Brum, Leonardo Bonato Felix, Thales Nicolau Prímola Gomes, and Antônio José Natali

Subjects
Cardiac Function, Cardiac Myocyte, Cardiac Remodeling, Physical Activity, Myocardial Infarction, Cardioprotection, Medicine (General), R5-920
Abstract

OBJECTIVES: The present study was performed to investigate 1) whether aerobic exercise training prior to myocardial infarction would prevent cardiac dysfunction and structural deterioration and 2) whether the potential cardiac benefits of aerobic exercise training would be associated with preserved morphological and contractile properties of cardiomyocytes in post-infarct remodeled myocardium. METHODS: Male Wistar rats underwent an aerobic exercise training protocol for eight weeks. The rats were then assigned to sham surgery (SHAM), sedentary lifestyle and myocardial infarction or exercise training and myocardial infarction groups and were evaluated 15 days after the surgery. Left ventricular tissue was analyzed histologically, and the contractile function of isolated myocytes was measured. Student's t-test was used to analyze infarct size and ventricular wall thickness, and the other parameters were analyzed by the Kruskal-Wallis test followed by Dunn's test or a one-way analysis of variance followed by Tukey's test (p

Published
2013

2. Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake

Author

Marcelo Perim Baldo, Divanei Zaniqueli, Ludimila Forechi, Rebeca Caldeira Machado, Sérgio Lamêgo Rodrigues, and José Geraldo Mill

Subjects
Hypertension, Salt Intake, Cardiac Hypertrophy, Ventricular Stiffness, Aldosterone Antagonism, Medicine (General), R5-920
Abstract

OBJECTIVE: To evaluate the effect of spironolactone on ventricular stiffness in spontaneously hypertensive adult rats subjected to high salt intake. INTRODUCTION: High salt intake leads to cardiac hypertrophy, collagen accumulation and diastolic dysfunction. These effects are partially mediated by cardiac activation of the renin-angiotensin-aldosterone system. METHODS: Male spontaneously hypertensive rats (SHRs, 32 weeks) received drinking water (SHR), a 1% NaCl solution (SHR-Salt), or a 1% NaCl solution with a daily subcutaneous injection of spironolactone (80 mg.kg-1) (SHRSalt- S). Age-matched normotensive Wistar rats were used as a control. Eight weeks later, the animals were anesthetized and catheterized to evaluate left ventricular and arterial blood pressure. After cardiac arrest, a doublelumen catheter was inserted into the left ventricle through the aorta to obtain in situ left ventricular pressurevolume curves. RESULTS: The blood pressures of all the SHR groups were similar to each other but were different from the normotensive controls (Wistar = 109±2; SHR = 118±2; SHR-Salt = 117±2; SHR-Salt-S = 116±2 mmHg; P

Published
2011
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3. Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats

Author

Antônio José Natali, Regiane Maria Soares Ramos, Márcia Ferreira da Silva, Izabel Regina dos Santos Costa Maldonado, Leonardo Bonato Felix, Luiz H. M. Bozi, Rômulo Dias Novaes, José Geraldo Mill, Thales Nicolau Prímola Gomes, Patricia Chakur Brum, Marcelo Perim Baldo, and José Bianco Nascimento Moreira

Subjects
Male, Cardiac function curve, medicine.medical_specialty, Time Factors, Physical Activity, Myocardial Infarction, Myocardial Infarction, Hemodynamics, Blood Pressure, Cardioprotection, Ventricular Function, Left, Random Allocation, Physical Conditioning, Animal, Internal medicine, medicine, Animals, Aerobic exercise, Myocytes, Cardiac, Myocardial infarction, cardiovascular diseases, Rats, Wistar, Cardiac Function, lcsh:R5-920, business.industry, Cardiac myocyte, Heart, General Medicine, medicine.disease, Myocardial Contraction, Cardiac Remodeling, Rats, Cardiovascular physiology, Basic Research, Blood pressure, Cardiology, cardiovascular system, Cardiac Myocyte, business, lcsh:Medicine (General)
Abstract

OBJECTIVES: The present study was performed to investigate 1) whether aerobic exercise training prior to myocardial infarction would prevent cardiac dysfunction and structural deterioration and 2) whether the potential cardiac benefits of aerobic exercise training would be associated with preserved morphological and contractile properties of cardiomyocytes in post-infarct remodeled myocardium. METHODS: Male Wistar rats underwent an aerobic exercise training protocol for eight weeks. The rats were then assigned to sham surgery (SHAM), sedentary lifestyle and myocardial infarction or exercise training and myocardial infarction groups and were evaluated 15 days after the surgery. Left ventricular tissue was analyzed histologically, and the contractile function of isolated myocytes was measured. Student's t-test was used to analyze infarct size and ventricular wall thickness, and the other parameters were analyzed by the Kruskal-Wallis test followed by Dunn's test or a one-way analysis of variance followed by Tukey's test (p

Published
2013

4. Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake

Author

Divanei Zaniqueli, Marcelo Perim Baldo, Ludimila Forechi, Rebeca Caldeira Machado, Sérgio Lamêgo Rodrigues, and José Geraldo Mill

Subjects
Male, medicine.medical_specialty, Time Factors, Cardiac Hypertrophy, Diastole, Blood Pressure, Spironolactone, Left ventricular hypertrophy, Muscle hypertrophy, chemistry.chemical_compound, Internal medicine, Rats, Inbred SHR, medicine, Ventricular Pressure, Animals, cardiovascular diseases, Salt intake, Rats, Wistar, Sodium Chloride, Dietary, Mineralocorticoid Receptor Antagonists, lcsh:R5-920, Analysis of Variance, business.industry, General Medicine, Aldosterone Antagonism, medicine.disease, musculoskeletal system, Rats, Ventricular Stiffness, medicine.anatomical_structure, Endocrinology, Blood pressure, Basic Research, chemistry, Ventricle, Hypertension, Ventricular pressure, cardiovascular system, Linear Models, Salt Intake, Hypertrophy, Left Ventricular, business, lcsh:Medicine (General), circulatory and respiratory physiology
Abstract

OBJECTIVE: To evaluate the effect of spironolactone on ventricular stiffness in spontaneously hypertensive adult rats subjected to high salt intake. INTRODUCTION: High salt intake leads to cardiac hypertrophy, collagen accumulation and diastolic dysfunction. These effects are partially mediated by cardiac activation of the renin-angiotensin-aldosterone system. METHODS: Male spontaneously hypertensive rats (SHRs, 32 weeks) received drinking water (SHR), a 1% NaCl solution (SHR-Salt), or a 1% NaCl solution with a daily subcutaneous injection of spironolactone (80 mg.kg-1) (SHR-Salt-S). Age-matched normotensive Wistar rats were used as a control. Eight weeks later, the animals were anesthetized and catheterized to evaluate left ventricular and arterial blood pressure. After cardiac arrest, a double-lumen catheter was inserted into the left ventricle through the aorta to obtain in situ left ventricular pressure-volume curves. RESULTS: The blood pressures of all the SHR groups were similar to each other but were different from the normotensive controls (Wistar = 109±2; SHR = 118±2; SHR-Salt = 117±2; SHR-Salt-S = 116±2 mmHg; P

Published
2011

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