1. Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances.
- Author
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Liu WY, Wang ZB, Zhang LC, Wei X, and Li L
- Subjects
- Animals, Blood-Brain Barrier anatomy & histology, Blood-Brain Barrier ultrastructure, Claudins physiology, Cytoplasm physiology, Environment, Hormones physiology, Humans, Neural Cell Adhesion Molecules physiology, Occludin physiology, Tight Junction Proteins, Blood-Brain Barrier physiology, Tight Junctions physiology, Tight Junctions ultrastructure
- Abstract
Blood-brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic substance in and out of the central nervous system (CNS), and plays a crucial role in maintaining a stable circumstance of the CNS. Tight junctions among adjacent cells form the basic structure of BBB to limiting paracellular permeability. In the present review, the constituents of tight junction proteins are depicted in detail, together with the regulation of tight junction under stimulation and in pathological conditions. Tight junction modulators are also discussed., (© 2012 Blackwell Publishing Ltd.)
- Published
- 2012
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