1. Negative Regulation of Cytokine Signaling in Immunity
- Author
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Hiroko Nakatsukasa, Minako Ito, Akihiko Yoshimura, Takashi Akanuma, and Shunsuke Chikuma
- Subjects
0301 basic medicine ,Innate immune system ,Suppressor of cytokine signaling 1 ,medicine.medical_treatment ,Biology ,Suppressor of cytokine signalling ,General Biochemistry, Genetics and Molecular Biology ,Cell biology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Cytokine ,Gene Expression Regulation ,PERSPECTIVES ,030220 oncology & carcinogenesis ,medicine ,Transcriptional regulation ,Animals ,Cytokines ,Humans ,SOCS3 ,Janus kinase ,Signal Transduction ,Proto-oncogene tyrosine-protein kinase Src - Abstract
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of transcription (JAK-STAT) pathway to promote gene transcriptional regulation, but their signals must be attenuated by multiple mechanisms. These include the suppressors of cytokine signaling (SOCS) family of proteins, which represent a main negative regulation mechanism for the JAK-STAT pathway. Cytokine-inducible Src homology 2 (SH2)-containing protein (CIS), SOCS1, and SOCS3 proteins regulate cytokine signals that control the polarization of CD4(+) T cells and the maturation of CD8(+) T cells. SOCS proteins also regulate innate immune cells and are involved in tumorigenesis. This review summarizes recent progress on CIS, SOCS1, and SOCS3 in T cells and tumor immunity.
- Published
- 2017
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