1. Contact-active antibacterial aerogels from cellulose nanofibrils.
- Author
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Henschen, Jonatan, Illergård, Josefin, Larsson, Per A., Ek, Monica, and Wågberg, Lars
- Subjects
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AEROGELS , *ANTIBACTERIAL agents , *CELLULOSE nanocrystals , *POLYACRYLIC acid , *PHARMACODYNAMICS , *SURFACE area - Abstract
The use of cellulose aerogels as antibacterial materials has been investigated by applying a contact-active layer-by-layer modification to the aerogel surface. Studying the adsorption of multilayers of polyvinylamine (PVAm) and polyacrylic acid to aerogels comprising crosslinked cellulose nanofibrils and monitoring the subsequent bacterial adhesion revealed that up to 26 mg PVAm g aerogel −1 was adsorbed without noticeably affecting the aerogel structure. The antibacterial effect was tested by measuring the reduction of viable bacteria in solution when the aerogels were present. The results show that >99.9% of the bacteria adhered to the surface of the aerogels. Microscopy further showed adherence of bacteria to the surfaces of the modified aerogels. These results indicate that it is possible to create materials with three-dimensional cellulose structures that adsorb bacteria with very high efficiency utilizing the high specific surface area of the aerogels in combination with their open structure. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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