1. Dye-cored polylysine dendrimer as luminescent nanoplatform for imaging-guided anticancer drug delivery.
- Author
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Zhu, Pengyu, Younis, Muhammad Rizwan, Ma, Guiqi, Zhang, Qianting, An, Ruibing, Wang, Kaiqi, and Dong, Jian
- Subjects
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ANTINEOPLASTIC agents , *BLOOD circulation , *POLYMERSOMES , *PLATINUM , *OVARIAN cancer , *OPTICAL images - Abstract
Dendrimers have numerous applications in imaging and drug delivery. Designing a dendrimer diagnostic platform with a well-defined structure and controlled drug delivery is a formidable challenge. Here, we design dendritic polymer-platinum conjugates (G5-PEG-Pt) as pH-responsive nanovesicles for imaging-guided platinum drug delivery. The G5-PEG-Pt have a well-defined structure, intrinsically bright fluorescence, and acid-responsive drug release. The pH-responsive G5-PEG-Pt could rapidly release the platinum drug at acidic pH (5.0) than neutral pH (7.4). The G5-PEG-Pt could enter SKOV-3 human ovarian cancer cells by the endocytosis pathway and exhibited comparative cytotoxicity to free cisplatin. By virtue of the prolonged blood circulation time and the enhanced permeability and retention (EPR) effect, a 4.4-fold higher tumor platinum uptake than that of free cisplatin was achieved, potentially enhancing the therapeutic indexes of the platinum drug. Therefore, these pH-responsive platinum and fluorescent dendrimer conjugates are expected to be potent in vivo cancer optical imaging and therapy platforms. [Display omitted] • The fluorescent dendritic polymer-platinum conjugates (G5-PEG-Pt) were prepared. • G5-PEG-Pt can be used for imaging-guided platinum drug delivery. • G5-PEG-Pt can rapidly release platinum under the acidic environment. • G5-PEG-Pt with prolonged blood circulation can efficiently accumulate into tumor. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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