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[Display omitted] • Bi3+ induces the gelatinization of ALG and reacts with Na 2 S. • The Bi 2 S 3 NPs enable the CT imaging and the enhancement of tumor RT. • The sensitized RT enhances the hypoxia of TME and activates TPZ. • The Bi 2 S 3 NPs generate the hyperthermia to eradicate the cancer cells. Radiotherapy (RT) is becoming a pervasive therapeutic pattern in clinical cancer therapy. However, the hypoxic microenvironment of tumors has a strong resistance to radiotherapy and could lead to a potential recurrence and metastasis after the treatment. Therefore, the use of synergistic strategies for improving and supplementing the RT efficiency is important. Herein, a novel Bi 2 S 3 /alginate (ALG) hydrogel containing tirapazamine (TPZ) was designed for the effective suppression of tumor recurrence, by introducing Bi3+ into the ALG, Na 2 S and TPZ solution. In this formulation, Bi3+ was used to crosslink with the ALG to form the hydrogel and react with S2− to simultaneously form Bi 2 S 3 nanoparticles in the hydrogel matrix. The resulting Bi 2 S 3 nanoparticles not only exhibit the superb radiosensitization effect to boost the effective eradication of tumors during RT but also manifest an excellent photothermal transforming performance for tumor hyperthermia and computed tomography (CT) imaging capacity for tumor monitoring. Furthermore, the RT caused hypoxia could activate the reductive prodrug TPZ and enhance its therapeutic efficiency. The reported hydrogel system provides an efficient and safe therapeutic strategy for current local tumor therapy. [ABSTRACT FROM AUTHOR]

[Display omitted] • MXene-based nanofibrous membrane for the multi-modal antibacterial applications. • The nanofibrous membranes can control the release of antibiotics. • Hyperthermia can destroy bacteria and further promote AMX release. • The nanofibrous membrane as a physical barrier promotes the wound healing. Featured with a three-dimensional network structure, electrostatic spinning nanofibrous membranes can maintain the hygroscopic balance in the wound place and promote the wound healing, thus have been extensively studied as a promising wound healing dressing. In this study, amoxicillin (AMX), MXene, and polyvinyl alcohol (PVA) were mixed and electrospun into an antibacterial nanofibrous membrane (MXene-AMX-PVA nanofibrous membrane). In the composite nanofibrous membrane, the PVA matrix could control the release of AMX to combat bacterial infection, while the MXene could transform the near-infrared laser into heat, leading to local hyperthermia to promote the AMX release. Meanwhile, the local hyperthermia could also destroy the noncellular components of bacteria and synergistically cause the bacterial inactivation. The bacteriostatic activity and wound healing ability of the composite nanofibrous membrane were systematically verified on the S. aureus in vitro and the S. aureus -infected mouse skin defect model in vivo. This membrane not only functioned as a physical barrier to co-load the AMX and MXene, but also exhibited the high antibacterial and accelerated wound healing capacity, which will advance the design of novel wound healing dressings and antibacterial strategies. [ABSTRACT FROM AUTHOR]

Recently, the healing of chronic wounds such as extensive burns has become a serious and intractable clinical problem. Avoiding wound infection and retaining an appropriate level of moisture around wounds are significant challenges in wound care. Herein, a dual-network hydrogel composed of sodium alginate (SA) and platelet-rich plasma (PRP) was designed to facilitate the wound healing. The preparation of hydrogel was achieved through a simple one-step thrombin activation process. The morphological characterization results revealed the three-dimensional network structure of the hydrogel. Then, certain levels of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) were detected in phosphate buffer solution (PBS) cultured hydrogel, which led to the possibility of cell proliferation and vascular regeneration. When topically applied to the wound skin of rats, the hydrogel presented high wound closure effectiveness. In conclusion, this strategy provides a simple and feasible approach to overcoming the shortcomings of conventional wound dressings. [Display omitted] • A dual-network hydrogel composed of sodium alginate and platelet-rich plasma. • The hydrogel releases epidermal growth and vascular endothelial growth factors. • The hydrogel presents high wound closure and wound healing effectiveness. [ABSTRACT FROM AUTHOR]