1. Construction of reduction-sensitive heterodimer prodrugs of doxorubicin and dihydroartemisinin self-assembled nanoparticles with antitumor activity.
- Author
-
Ren, Guolian, Duan, Danyu, Wang, Geng, Wang, Rongrong, Li, Yujie, Zuo, Hengtong, Zhang, Qichao, Zhang, Guoshun, Zhao, Yongdan, Wang, Ruili, and Zhang, Shuqiu
- Subjects
- *
HETERODIMERS , *DOXORUBICIN , *ANTINEOPLASTIC agents , *PRODRUGS , *NANOPARTICLES , *IN vitro studies - Abstract
Doxorubicin (DOX) is used as a first-line chemotherapeutic drug, whereas dihydroartemisinin (DHA) also shows a certain degree of antitumor activity. Disulfide bonds (-SS-) in prodrug molecules can be degraded in highly reducing environments. Thus, heterodimer prodrugs of DOX and DHA linked by a disulfide bond was designed and subsequently prepared as reduction-responsive self-assembled nanoparticles (DOX-SS-DHA NPs). In an in vitro release study, DOX-SS-DHA NPs exhibited reduction-responsive activity. Upon cellular evaluation, DOX-SS-DHA NPs were found to have better selectivity toward tumor cells and less cytotoxicity to normal cells. Compared to free DiR, DOX-SS-DHA NPs showed improved accumulation at the tumor site and even had a longer clearance half-life. More importantly, DOX-SS-DHA NPs possessed a much higher tumor inhibition efficacy than DOX-sol and MIX-sol in 4T1 tumor-bearing mice. Our results suggested the superior antitumor efficacy of DOX-SS-DHA NPs with less cytotoxicity. [Display omitted] • A novel heterodimer prodrug (DOX-SS-DHA) was synthesized to take advantages of the combination therapy. • In vitro efficacy studies of the designed DOX-SS-DHA NPs showed enhanced tumor suppression and improved survival time. • DOX-SS-DHA NPs prepared here had better security to mice and better selectivity to the tumor sites of mice. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF