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Your search keyword '"Songchao Tang"' showing total 2 results
Start Over Author "Songchao Tang" Journal colloids and surfaces b: biointerfaces
2 results on '"Songchao Tang"'

1. Stimulation of cell responses and bone ingrowth into macro-microporous implants of nano-bioglass/polyetheretherketone composite and enhanced antibacterial activity by release of hinokitiol

Author

Yuan Yao, Lili Yang, Wu Wei, Xuehong Wang, Jie Wei, Yongkang Pan, Hua Hong, Songchao Tang, Jue Zhang, and Tinglan Wang

Subjects
Ceramics, Polymers, Cell, Composite number, Colony Count, Microbial, Bone Morphogenetic Protein 2, 02 engineering and technology, 01 natural sciences, Apatite, Polyethylene Glycols, Mice, chemistry.chemical_compound, Colloid and Surface Chemistry, Implants, Experimental, X-Ray Diffraction, Apatites, Cytoskeleton, Minerals, Surfaces and Interfaces, General Medicine, Ketones, 021001 nanoscience & nanotechnology, Anti-Bacterial Agents, Body Fluids, medicine.anatomical_structure, visual_art, visual_art.visual_art_medium, 0210 nano-technology, Antibacterial activity, Porosity, Biotechnology, Biocompatibility, Simulated body fluid, Microbial Sensitivity Tests, 010402 general chemistry, Bone and Bones, Tropolone, Cell Line, Benzophenones, Hinokitiol, medicine, Animals, Physical and Theoretical Chemistry, Cell Shape, Cell Proliferation, Bone Development, Microbial Viability, X-Ray Microtomography, Microporous material, Alkaline Phosphatase, 0104 chemical sciences, Drug Liberation, chemistry, Monoterpenes, Nanoparticles, Biomedical engineering
Abstract

Poor osteogenesis and bacterial infection lead to the failure of implants, thus enhancements of osteogenic activity and antibacterial activity of the implants have significances in orthopedic applications. In this study, macro-microporous bone implants of nano-bioglass (nBG) and polyetheretherketone (PK) composite (mBPC) were fabricated. The results indicated that the mBPC with the porosity of around 70% exhibited interconnected macropores (sizes of about 400 μm) and micropores (sizes of about 10 μm). The apatite mineralization ability of mBPC in simulated body fluid (SBF) was significantly improved compared with macroporous nBG/PK composite (BPC) without micropores and macroporous PK (mPK). Drug of hinokitiol (HK) was loaded into mBPC (dmBPC), which displayed excellent in vitro antibacterial activity against Staphylococcus aureus. The MC3T3-E1 cells proliferation and ALP activity were significantly promoted by mBPC and dmBPC as compared with BPC and mPK. The micro-CT and histological evaluation showed that both mBPC and dmBPC containing nBG and micropores induced higher new bone formation into porous implants than mPK and BPC. The immunohistochemistry analysis indicated that the expression of BMP-2 in mBPC and dmBPC exhibited obviously higher level than mPK and BPC. The results suggested that the incorporation of nBG and micropores in mBPC obviously improved the osteogenic activity, and mBPC load with HK also promoted osteogenesis, indicating good biocompatibility. The dmBPC with HK significantly enhanced osteogenesis and antibacterial activity, which had great potential as bone implant for hard tissue repair.

Published
2018

2. Influences of sodium tantalite submicro-particles in polyetheretherketone based composites on behaviors of rBMSCs/HGE-1 cells for dental application

Author

Lili Yang, Songchao Tang, Yun Kyung Jung, Dongliang Wang, Xuening Shen, Chao Gao, Jung-Woog Shin, Jie Wei, Lishu Ren, and Axiang He

Subjects
Materials science, Biocompatibility, Polymers, Surface Properties, Tantalite, Biocompatible Materials, Tantalum, 02 engineering and technology, engineering.material, Bone tissue, 01 natural sciences, Polyethylene Glycols, Benzophenones, Colloid and Surface Chemistry, Adsorption, Materials Testing, 0103 physical sciences, Cell Adhesion, Peek, medicine, Animals, Humans, Particle Size, Physical and Theoretical Chemistry, Composite material, Cell Proliferation, Dental Implants, 010304 chemical physics, Epithelial Cells, Mesenchymal Stem Cells, Oxides, Surfaces and Interfaces, General Medicine, Adhesion, Ketones, 021001 nanoscience & nanotechnology, Surface energy, Rats, medicine.anatomical_structure, Compressive strength, engineering, 0210 nano-technology, Biotechnology
Abstract

Dental implanted materials require excellent mechanical properties, biocompatibility as well as integration with bone tissue and gingival tissue to achieve early loading and long-term stability. In this study, cubic shape sodium tantalite (ST) submicro-particles with the size of around 180 nm were synthesized by a hydrothermal method, and ST/polyetheretherketone (PEEK) composites (TPC) with ST content of 20 w% (TPC20) and 40 w% (TPC40) were prepared by melting blend. The results showed that the compressive strength, thermal properties, surface roughness, hydrophilicity and surface energy as well as adsorption of proteins on TPC40 were also significantly enhanced compared with TPC20 and PEEK. Moreover, the responses (adhesion and proliferation as well as differentiation) of rat bone marrow mesenchymal stem cells (rBMSCs), and responses (adhesion, and proliferation) of human gingival epithelial (HGE-1) cells to TPC40 were significantly promoted compared with TPC20 and PEEK. The results demonstrated that ST content in TPC had remarkable effects on the surface properties, which played key roles in stimulating the responses of both rBMSCs and HGE-1 cells. TPC40 with increased surface properties and excellent cytocompatibility might have great potential as an implanted material for dental application.

Published
2020

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