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In order to replace conventional sutures in wound closing applications, favorable hydrogels with strong wet tissue adhesion and biocompatibility have attracted considerable attention. Herein, inspired by mussel adhesive protein, a series of dopamine modified carboxymethyl cellulose (CMC-DA) hydrogels were prepared in situ using enzymatic crosslinking in the presence of horseradish peroxidase (HRP) and H 2 O 2 . The biomimetic CMC-DA hydrogel exhibited about 6-fold enhanced wet tissue adhesion strength (28.5 kPa) over the commercial fibrin glue. In addition, the gelation time, swelling ratio and rheological property of the hydrogel can be simply controlled by changing the concentrations of HRP, H 2 O 2 , and CMC-DA polymer. The gels also exhibited good biodegradation and biocompatibility in vitro. The overall results show that the CMC-DA hydrogel with enhanced wet adhesiveness will be a promising tissue adhesive material., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Whereby cholesterol presents one of the major fatty substances in human body, carboxymethyl cellulose is a water-soluble derivative of cellulose, the most abundant dietary fiber. Whereas on one hand in vivo precipitation of cholesterol is the major cause of atherosclerosis, dietary fibers are on the other hand known for their ability to clean the fatty plaque deposited on intestinal pathways, and prevent its build-up in other critical areas within the organism. In this work, a method for the preparation of a composite material comprising cholesterol and carboxymethyl cellulose from 1-hexanol/water biphase mixtures is reported. Specificity of the interaction between the composite components in the given conditions of synthesis inhibits the tendency of solid cholesterol to adopt typical plate- or needle-shaped morphologies. Instead, control of the thixotropic behavior of the constituent polymer phase leads to the formation of bubbling, multi-layered cholesteric films. In view of the major illnesses that involve biological precipitation of cholesterol crystals, these findings may be considered as pointing towards the interactional specificity of potential chemotherapeutic and/or nutritional significance. Scanning electron microscopy, thermal and diffractometric analyses were performed as parts of the characterization of the prepared material.