1. The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.
- Author
-
Dai, Weiyu, Hong, Linjie, Xiao, Wushuang, Zhang, Luyu, Sha, Weihong, Yu, Zhen, Liu, Xuehua, Liu, Side, Xiao, Yizhi, Yang, Ping, Peng, Ying, Zhang, Jieming, Lin, Jianjiao, Wu, Xiaosheng, Tang, Weimei, Lin, Zhizhao, Xiang, Li, Li, Jiaying, Pei, Miaomiao, and Wang, Jide
- Subjects
- *
COLORECTAL cancer , *CELL proliferation , *CANCER cell proliferation , *CELL migration , *METASTASIS , *CELL growth - Abstract
Various miRNAs have been shown to participate in the tumor progression and development of colorectal cancer (CRC). However, the role of miR-3913-5p in CRC are yet to be clearly defined. In the present study, we determine that miR-3913-5p is downregulated in CRC cell lines and CRC tissues. Exogenous miR-3913-5p expression weakens the CRC cells growth, migration and invasion. Mechanistically, miR-3913-5p directly targets the 3'UTR of CREB5. Overexpression of CREB5 reverses the suppression of CRC cells proliferation, migration and invasion induced by miR-3913-5p. Furthermore, ATF2 negatively regulates the transcription of miR-3913-5p by binding to its promoter. CREB5 can cooperate with ATF2. CREB5 is required for ATF2 in regulating miR-3913-5p. Finally, inverse correlations can be found between the expressions of miR-3913-5p and CREB5 or ATF2 in CRC tissues. Thus, a plausible mechanism of ATF2/miR-3913-5p/CREB5 axis regulating CRC progression is elucidated. Our findings suggest that miR-3913-5p functions as a tumor suppressor in CRC. ATF2/miR-3913-5p/CREB5 axis might be a potential therapeutic target against CRC progression. The miRNA miR-3913-5p inhibits colorectal cancer cell proliferation, migration and invasion, in concert with its regulation of and by CREB5 and ATF2. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF