1. Estimating Incidence Rate on Current Status Data with Application to a Phase IV Cancer Trial.
- Author
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Rai, SheshN., Pan, Jianmin, Yuan, Xiaobin, Sun, Jianguo, Hudson, MelissaM., and Srivastava, DeoK.
- Subjects
CANCER research ,ESTIMATION theory ,DATA analysis ,CLINICAL trials ,DRUG development ,SURVIVAL analysis (Biometry) - Abstract
New drug discovery in the pediatrics has dramatically improved survival, but with long- term adverse events. This motivates the examination of adverse outcomes such as long-term toxicity in a phase IV trial. An ideal approach to monitor long-term toxicity is to systematically follow the survivors, which is generally not feasible. Instead, cross-sectional surveys are conducted in Hudson et al. (2007), with one of the objectives to estimate the cumulative incidence rates along with specific interest in fixed-term (5 or 10 year) rates. We present inference procedures based on current status data to our motivating example with very interesting findings. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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