1. Genetic variability in swine leukocyte antigen class II and Toll-like receptors affects immune responses to vaccination for bacterial infections in pigs.
- Author
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Shinkai H, Arakawa A, Tanaka-Matsuda M, Ide-Okumura H, Terada K, Chikyu M, Kawarasaki T, Ando A, and Uenishi H
- Subjects
- Actinobacillus Infections immunology, Actinobacillus Infections prevention & control, Actinobacillus pleuropneumoniae immunology, Animals, Antibodies, Bacterial biosynthesis, Antibodies, Bacterial immunology, Chromosome Mapping, Erysipelothrix immunology, Erysipelothrix Infections immunology, Female, Genetic Variation, Genotyping Techniques, Histocompatibility Antigens Class II genetics, Histocompatibility Antigens Class II immunology, Male, Swine, Swine Diseases immunology, Toll-Like Receptor 1 genetics, Toll-Like Receptor 1 immunology, Toll-Like Receptor 4 genetics, Toll-Like Receptor 4 immunology, Toll-Like Receptor 5 genetics, Toll-Like Receptor 5 immunology, Toll-Like Receptor 6 genetics, Toll-Like Receptor 6 immunology, Vaccines, Inactivated, Actinobacillus Infections veterinary, Bacterial Vaccines immunology, Erysipelothrix Infections prevention & control, Swine Diseases prevention & control, Vaccination
- Abstract
The genes encoding swine leukocyte antigen (SLA) and Toll-like receptor (TLR) are highly polymorphic in pig populations, and likely have influences on infection and the effects of vaccination. We explored the associations of different genotypes of SLA class II and of the genes TLR1, TLR4, TLR5, and TLR6 with antibody responses after vaccination against Erysipelothrix rhusiopathiae (ER) and Actinobacillus pleuropneumoniae (APP) serotypes 1, 2, and 5 in 191 Duroc pigs maintained under specific pathogen-free conditions. We demonstrated close relationships between SLA class II and ER antibody response and between TLR genes other than TLR4 and APP antibody responses. Pigs with specific haplotypes in SLA class II or TLR5 showed decreased antibody response to ER vaccination or increased responses to APP2 and APP5 vaccination, respectively. It might be possible to breed for responsiveness to vaccination and to implement new vaccine development strategies unaffected by genetic backgrounds of pigs., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2012
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