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Abstract: In this paper, we consider how to recover the structure of a Bayesian network from a moral graph. We present a more accurate characterization of moral edges, based on which a complete subset (i.e., a separator) contained in the neighbor set of one vertex of the putative moral edge in some prime block of the moral graph can be chosen. This results in a set of separators needing to be searched generally smaller than the sets required by some existing algorithms. A so-called structure-finder algorithm is proposed for structural learning. The complexity analysis of the proposed algorithm is discussed and compared with those for several existing algorithms. We also demonstrate how to construct the moral graph locally from, separately, the Markov blanket, domain knowledge and -separation trees. Simulation studies are used to evaluate the performances of various strategies for structural learning. We also analyze a gene expression data set by using the structure-finder algorithm. [Copyright &y& Elsevier]

Abstract: In cancer classification based on gene expression data, it would be desirable to defer a decision for observations that are difficult to classify. For instance, an observation for which the conditional probability of being cancer is around 1/2 would preferably require more advanced tests rather than an immediate decision. This motivates the use of a classifier with a reject option that reports a warning in cases of observations that are difficult to classify. In this paper, we consider a problem of gene selection with a reject option. Typically, gene expression data comprise of expression levels of several thousands of candidate genes. In such cases, an effective gene selection procedure is necessary to provide a better understanding of the underlying biological system that generates data and to improve prediction performance. We propose a machine learning approach in which we apply the penalty to the SVM with a reject option. This method is referred to as the SVM with a reject option. We develop a novel optimization algorithm for this SVM, which is sufficiently fast and stable to analyze gene expression data. The proposed algorithm realizes an entire solution path with respect to the regularization parameter. Results of numerical studies show that, in comparison with the standard SVM, the proposed method efficiently reduces prediction errors without hampering gene selectivity. [Copyright &y& Elsevier]