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The genus Salvia (sage) is one of the largest and the most important Lamiaceae family genera of medicinal and aromatic plants, which is widespread throughout the world. S. officinalis and S. sclarea are the most thoroughly studied Salvia species, whereas the information about phytochemicals in many other Salvia species are rather scarce. The aim of this study was comprehensive evaluation of antioxidant potential and phytochemical composition of products isolated by high pressure extraction methods. Supercritical carbon dioxide extraction (SFE-CO2), pressurized liquid extraction (PLE) with various polarity solvents were used for separating sage herb into several soluble fractions. Total content of phenolic compounds (TPC) was analysed by UV-spectrophotometry method using Folin-Ciocalteu reagent. The antioxidant activity of extracts was evaluated using ABTS+• scavenging and ORAC assays. Individual polyphenolic constituents were analysed by UPLC-Q/TOF-MS. SFE-CO2 of Salvia spp. yielded from 1.84±0.03% (S. stepposa) to 5.22±0.2% (S. sclarea) of lipophilic fraction. Further PLE of SFE-CO2 residues was performed consecutively using ethanol (96%) and water. The highest yields were obtained with water (30.2±0.18- 43.7±0.14%). TPC and antioxidant properties of the analysed Salvia spp. extracts were largely dependent on the extraction solvent. Ethanol extracts possessed significantly higher antioxidant capacity and TPC comparing to the extracts isolated with other solvents. Results also show that rosmarinic acid was a major quantitatively compound in the analysed Salvia spp. extracts. In conclusion, the results obtained may serve as valuable information for the valorisation of Salvia herbs as raw materials for the isolation of functional ingredients for human nutrition and other purposes. [ABSTRACT FROM AUTHOR]