1. Hemodynamically significant patent ductus arteriosus and the development of bronchopulmonary dysplasia
- Author
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Kent A. Willis and Mark F. Weems
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,behavioral disciplines and activities ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Ductus arteriosus ,mental disorders ,Epidemiology ,Medicine ,Radiology, Nuclear Medicine and imaging ,Mechanical ventilation ,business.industry ,Pulmonary Complication ,Gestational age ,General Medicine ,medicine.disease ,Clinical trial ,medicine.anatomical_structure ,Bronchopulmonary dysplasia ,Premature birth ,Pediatrics, Perinatology and Child Health ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
Patent ductus arteriosus (PDA) is prevalent in premature newborns and has been linked to the development of bronchopulmonary dysplasia (BPD), a serious pulmonary complication of premature birth. Although a causal relationship has not been proven, the link is greatest among infants born at lower gestational age who are treated with mechanical ventilation in the presence of a large ductal shunt. Despite strong association in epidemiological studies, treatment of a patent ductus arteriosus has not been shown to prevent BPD, and some therapies may increase the risk of BPD. We describe preclinical and clinical data demonstrating the association of a PDA with BPD, highlight the effects of surgical and pharmacological treatment, and explore the implications of recent clinical trials for the management of PDA in the premature newborn.
- Published
- 2018
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