1. Allergic contact dermatitis due to the liquid skin adhesive Dermabond® predominantly occurs after the first exposure
- Author
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Naoko Inomata, Nao Koh, Chika Asai, Megumi Sato, Seiko Goda, Hideyuki Ishikawa, Michiko Aihara, and Masako Tanaka
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Dermatology ,Cross Reactions ,law.invention ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,Postoperative Complications ,0302 clinical medicine ,law ,medicine ,Humans ,Immunology and Allergy ,Cyanoacrylates ,030212 general & internal medicine ,Allergic contact dermatitis ,Sensitization ,Retrospective Studies ,Aron alpha ,business.industry ,Patch test ,Middle Aged ,Patch Tests ,medicine.disease ,Ethyl cyanoacrylate ,2-Octyl cyanoacrylate ,medicine.anatomical_structure ,chemistry ,Cyanoacrylate ,Dermatitis, Allergic Contact ,Female ,Tissue Adhesives ,Adhesive ,business - Abstract
BACKGROUND The clinical characteristics of patients with allergic contact dermatitis (ACD) due to a skin adhesive containing 2-octyl cyanoacrylate, Dermabond®, have not yet been elucidated. OBJECTIVE To investigate the clinical characteristics of patients with ACD caused by Dermabond® application. METHODS In this retrospective study, 577 patch tested patients were included. We identified patients with positive patch test results for Dermabond® and evaluated their results concerning (meth)acrylates and ethyl cyanoacrylate adhesive. RESULTS Nine patients had positive patch test results to Dermabond®; six had developed secondary generalization.The mean time between Dermabond® application and ACD onset was 34 days (range, 27-44) in six patients with ACD after the first use, whereas, in the other three patients, it was 5.6 days (range, 4-8) after the second use. The time was significantly different between the two groups (P
- Published
- 2020