1. Rule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department
- Author
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Stefania Battista, Corrado Moiraghi, Emilio Hirsch, Maria Manzo, Enrico Lupia, Fulvio Morello, Manuela Lucchiari, Giulio Mengozzi, E. Saglio, Francesca Giachino, and M Loiacono
- Subjects
Male ,Acute coronary syndrome ,medicine.medical_specialty ,Critical Care and Intensive Care Medicine ,Gastroenterology ,Cohort Studies ,Aortic aneurysm ,Aneurysm ,Interquartile range ,Internal medicine ,medicine ,Humans ,Single-Blind Method ,Prospective Studies ,Prospective cohort study ,Aged ,Aortic dissection ,business.industry ,Research ,Area under the curve ,Emergency department ,Middle Aged ,medicine.disease ,Aortic Aneurysm ,Surgery ,Aortic Dissection ,Matrix Metalloproteinase 8 ,Acute Disease ,Female ,Emergency Service, Hospital ,business - Abstract
Introduction Matrix metalloproteinases (MMPs) are involved in aortic pathophysiology. Preliminary studies have detected increased plasma levels of MMP8 and MMP9 in patients with acute aortic dissection (AAD). However, the performance of plasma MMP8 and MMP9 for the diagnosis of AAD in the emergency department is at present unknown. Methods The levels of MMP8 and MMP9 were measured by ELISA on plasma samples obtained from 126 consecutive patients evaluated in the emergency department for suspected AAD. All patients were subjected to urgent computed tomography (CT) scan for final diagnosis. Results In the study cohort (N = 126), AAD was diagnosed in 52 patients and ruled out in 74 patients. Median plasma MMP8 levels were 36.4 (interquartile range 24.8 to 69.3) ng/ml in patients with AAD and 13.2 (8.1 to 31.8) ng/ml in patients receiving an alternative final diagnosis (P
- Published
- 2013
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