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Your search keyword '"Mouktaroudi, Maria"' showing total 4 results
Start Over Author "Mouktaroudi, Maria" Journal critical care
4 results on '"Mouktaroudi, Maria"'

1. Risk assessment in sepsis: a new prognostication rule by APACHE II score and serum soluble urokinase plasminogen activator receptor

Author

Giamarellos-Bourboulis, Evangelos J, primary, Norrby-Teglund, Anna, additional, Mylona, Vassiliki, additional, Savva, Athina, additional, Tsangaris, Iraklis, additional, Dimopoulou, Ioanna, additional, Mouktaroudi, Maria, additional, Raftogiannis, Maria, additional, Georgitsi, Marianna, additional, Linnér, Anna, additional, Adamis, George, additional, Antonopoulou, Anastasia, additional, Apostolidou, Efterpi, additional, Chrisofos, Michael, additional, Katsenos, Chrisostomos, additional, Koutelidakis, Ioannis, additional, Kotzampassi, Katerina, additional, Koratzanis, George, additional, Koupetori, Marina, additional, Kritselis, Ioannis, additional, Lymberopoulou, Korina, additional, Mandragos, Konstantinos, additional, Marioli, Androniki, additional, Sundén-Cullberg, Jonas, additional, Mega, Anna, additional, Prekates, Athanassios, additional, Routsi, Christina, additional, Gogos, Charalambos, additional, Treutiger, Carl-Johan, additional, Armaganidis, Apostolos, additional, and Dimopoulos, George, additional

Published
2012
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2. Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia

Author

Giamarellos-Bourboulis, Evangelos J, primary, van de Veerdonk, Frank L, additional, Mouktaroudi, Maria, additional, Raftogiannis, Maria, additional, Antonopoulou, Anastasia, additional, Joosten, Leo AB, additional, Pickkers, Peter, additional, Savva, Athina, additional, Georgitsi, Marianna, additional, van der Meer, Jos WM, additional, and Netea, Mihai G, additional

Published
2011
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3. Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts

Author

Kumpf, Oliver, primary, Giamarellos-Bourboulis, Evangelos J, additional, Koch, Alexander, additional, Hamann, Lutz, additional, Mouktaroudi, Maria, additional, Oh, Djin-Ye, additional, Latz, Eicke, additional, Lorenz, Eva, additional, Schwartz, David A, additional, Ferwerda, Bart, additional, Routsi, Christina, additional, Skalioti, Chryssanthi, additional, Kullberg, Bart-Jan, additional, van der Meer, Jos WM, additional, Schlag, Peter M, additional, Netea, Mihai G, additional, Zacharowski, Kai, additional, and Schumann, Ralf R, additional

Published
2010
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4. Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis

Author

Giamarellos-Bourboulis, Evangelos J, Tsaganos, Thomas, Spyridaki, Ekaterini, Mouktaroudi, Maria, Plachouras, Diamantis, Vaki, Ilia, Karagianni, Vassiliki, Antonopoulou, Anastasia, Veloni, Vassiliki, and Giamarellou, Helen

Subjects
Aged, 80 and over, CD4-Positive T-Lymphocytes, Male, Membrane Glycoproteins, Research, Prognosis, Survival Analysis, Triggering Receptor Expressed on Myeloid Cells-1, Cohort Studies, Killer Cells, Natural, Sepsis, Humans, Female, Lymphocyte Count, Receptors, Immunologic, Gram-Negative Bacterial Infections, Aged
Abstract

Introduction Our aim was to define early changes of lymphocytes and of NK cells in severe sepsis and to correlate them with serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1). Methods Blood was sampled from 49 patients with proven highly suspected infection by Gram-negative pathogens, within 12 hours of the advent of severe sepsis, and was also sampled from six healthy volunteers. White blood cells were targeted with monoclonal antibodies and were analyzed by flow cytometry. The concentrations of sTREM-1 were estimated by ELISA. Results The presence of CD3/CD4 cells was significantly lower (P < 0.0001) and that of NK cells significantly higher among patients with sepsis compared with controls (P = 0.011). The proportions (median ± standard error) of ANNEXIN-V/CD4/CD3-positive cells, of ANNEXIN-V/CD8/CD3-positive cells and of ANNEXIN-V/CD14-positive cells of the patient population were 7.41 ± 2.26%, 7.69 ± 3.42% and 1.96 ± 4.22%, respectively. Patients with NK cells >20% survived longer compared with those patients with NK cells ≤20% (P = 0.041), and patients with sTREM-1 concentrations >180 pg/ml survived longer compared with those patients with sTREM-1 concentrations ≤180 pg/ml (P = 0.042). A negative correlation was found between the percentages of ANNEXIN-V/CD4/CD3-positive cells and of CD3/CD4 cells (rs = -0.305, P = 0.049), and a positive correlation was found between the serum sTREM-1 concentration and the percentage of NK cells (rs = +0.395, P = 0.014). NK cells isolated from two healthy volunteers released sTREM-1 upon triggering with endotoxins. Conclusion Early severe sepsis is characterized by CD4-lymphopenia and increased NK cells, providing a survival benefit for the septic patient at percentages >20%. The survival benefit resulting from elevated NK cells might be connected to elevated serum levels of sTREM-1.

Published
2006

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