1. The authors reply.
- Author
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Rogers, Angela J., Desai, Menisha, Matthay, Michael A., Choi, Augustine M., and Baron, Rebecca M.
- Subjects
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ADULT respiratory distress syndrome , *PULMONARY fibrosis , *MEDICAL research , *INTERLEUKINS , *ANTILIPEMIC agents , *BLOOD plasma - Abstract
Specifically, rosuvastatin (used in the SAILS trial) is one of the more hydrophilic statins, and the hydrophilic statin pravastatin was associated with inflammasome activation enhanced bleomycin-induced lung inflammation in mice ([7]). Importantly, we view our results as a provocative hypothesis-generating study to facilitate future precision medicine-targeted treatment approaches for sepsis and ARDS. 2 Rogers AJ, Guan J, Trtchounian A. Association of elevated plasma interleukin-18 level with increased mortality in a clinical trial of statin treatment for acute respiratory distress syndrome. [Extracted from the article]
- Published
- 2020
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