1. Targeting the gut to prevent and counteract metabolic disorders and pathologies during aging
- Author
-
Dragan Milenkovic, Frédéric Capel, Lydie Combaret, Blandine Comte, Dominique Dardevet, Bertrand Evrard, Christelle Guillet, Laurent-Emmanuel Monfoulet, Alexandre Pinel, Sergio Polakof, Estelle Pujos-Guillot, Didier Rémond, Yohann Wittrant, Isabelle Savary-Auzeloux, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Plateforme Exploration du Métabolisme (PFEM), Institut National de la Recherche Agronomique (INRA)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-MetaboHUB-Clermont, MetaboHUB-MetaboHUB, Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), and INRAE, Université Clermont Auvergne
- Subjects
Aging ,age-related pathologies ,nutrition ,[SDV]Life Sciences [q-bio] ,microbiota ,gut ,inflammaging ,General Medicine ,[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Industrial and Manufacturing Engineering ,Food Science - Abstract
International audience; Impairment of gut function is one of the explanatory mechanisms of health status decline in elderly population. These impairments involve a decline in gut digestive physiology, metabolism and immune status, and associated to that, changes in composition and function of the microbiota it harbors. Continuous deteriorations are generally associated with the development of systemic dysregulations and ultimately pathologies that can worsen the initial health status of individuals. All these alterations observed at the gut level can then constitute a wide range of potential targets for development of nutritional strategies that can impact gut tissue or associated microbiota pattern. This can be key, in a preventive manner, to limit gut functionality decline, or in a curative way to help maintaining optimum nutrients bioavailability in a context on increased requirements, as frequently observed in pathological situations. The aim of this review is to give an overview on the alterations that can occur in the gut during aging and lead to the development of altered function in other tissues and organs, ultimately leading to the development of pathologies. Subsequently is discussed how nutritional strategies that target gut tissue and gut microbiota can help to avoid or delay the occurrence of aging-related pathologies.
- Published
- 2022