1. Decreased tissue oxygenation in newborns with congenital heart defects: a case-control study
- Author
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Darja Paro-Panjan, Domen Robek, Uroš Mazić, Petja Fister, and Helena Lenasi
- Subjects
Heart Defects, Congenital ,Male ,medicine.medical_specialty ,Respiratory rate ,Hemodynamics ,030204 cardiovascular system & hematology ,Kidney ,03 medical and health sciences ,0302 clinical medicine ,Heart Rate ,Internal medicine ,Heart rate ,medicine ,Humans ,Oximetry ,Intestinal Mucosa ,Spectroscopy, Near-Infrared ,business.industry ,Left Brain Hemisphere ,Infant, Newborn ,Case-control study ,Brain ,030208 emergency & critical care medicine ,General Medicine ,Clinical Science ,Oxygen ,Blood pressure ,medicine.anatomical_structure ,Tissue oxygenation ,Case-Control Studies ,Cardiology ,Female ,business - Abstract
Aim To compare regional tissue oxygenation (rSO2) in the brain, intestine, and kidney between newborns with and without congenital heart defects (CHD). Methods This observational case-control study was conducted at the Neonatal Deparetment of Children's Hospital Ljubljana between December 2012 and April 2014. It included 35 newborns with CHD and 30 healthy age- and sex-matched controls. CHD were assessed echocardiographically and divided into acyanotic and cyanotic group. RSO2 in the brain, intestine, and kidney was measured using near-infrared spectroscopy (NIRS). Simultaneously, heart rate (HR), breathing frequency (BF), mean arterial blood pressure (MAP), and arterial oxygen saturation (Sao2) were recorded. Results Newborns with CHD had significantly lower rSO2 in the left brain hemisphere (67 ± 11% vs 76 ± 8%, P = 0.004), right brain hemisphere (68 ± 11% vs 77 ± 8%, P
- Published
- 2018
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