1. Vaccines as Monotherapy and in Combination Therapy for Prostate Cancer.
- Author
-
Rotow, Julia, Gameiro, Sofia R., Madan, Ravi A., Gulley, James L., Schlom, Jeffrey, and Hodge, James W.
- Subjects
PROSTATE cancer ,CANCER vaccines ,DRUG therapy ,PREVENTIVE medicine - Abstract
Prostate cancer is the second leading cause of cancer death among men in the United States. Standard-of-care chemotherapy for metastatic castration-resistant prostate cancer is associated with significant but modest survival benefit, indicating a need for alternative and/or additional approaches. The use of therapeutic cancer vaccines for the treatment of prostate cancer represents a novel targeted therapeutic approach. Whereas vaccine strategies are being developed for the treatment of various stages of prostate cancer, this article focuses on novel vaccine strategies for castration-resistant prostate cancer that have been translated into late-stage clinical studies. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF